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FOXP4

{{Short description|Human protein-coding gene}}

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Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.{{cite web | title = Entrez Gene: FOXP4 forkhead box P4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116113}}

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. It also is a major factor in developing Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications for COVID-19 pandemic research.{{Cite journal|url=https://www.nature.com/articles/d41586-023-02269-2|title=Gene linked to long COVID found in analysis of thousands of patients|first=Heidi|last=Ledford|date=July 11, 2023|journal=Nature|volume=619 |issue=7970 |page=445 |via=www.nature.com|doi=10.1038/d41586-023-02269-2|pmid=37433943 |bibcode=2023Natur.619..445L |s2cid=259831412 |url-access=subscription}}{{Cite journal|url=https://www.nature.com/articles/s41588-025-02100-w|title=Genome-wide association study of long COVID|first=Vilma Lammi|last=Hanna M. Ollila|date=May 21, 2025|journal=Nature|via=www.nature.com|doi=10.1038/s41588-025-02100-w|url-access=subscription|doi-access=free}}

References

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Further reading

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  • {{cite journal |vauthors=Katoh M, Katoh M |title=Human FOX gene family (Review) |journal=Int. J. Oncol. |volume=25 |issue= 5 |pages= 1495–500 |year= 2005 |pmid= 15492844 |doi= 10.3892/ijo.25.5.1495}}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Lu MM, Li S, Yang H, Morrisey EE |title=Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues |journal=Gene Expr. Patterns |volume=2 |issue= 3–4 |pages= 223–8 |year= 2003 |pmid= 12617805 |doi=10.1016/S1567-133X(02)00058-3 |doi-access=free }}{{Retracted|doi=10.1016/S0925-4773(03)00085-6|intentional=yes}}
  • {{cite journal | author=Teufel A |title=FoxP4, a novel forkhead transcription factor |journal=Biochim. Biophys. Acta |volume=1627 |issue= 2–3 |pages= 147–52 |year= 2003 |pmid= 12818433 |doi= 10.1016/S0167-4781(03)00074-5| author2=Wong EA | author3=Mukhopadhyay M | last4=Malik | first4=N | last5=Westphal | first5=H |url=https://zenodo.org/record/1259887 }}
  • {{cite journal |vauthors=Lu MM, Li S, Yang H, Morrisey EE |title=Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues |journal=Mech. Dev. |volume=119 |pages= S197–202 |year= 2002|issue=Suppl 1 |pmid= 14516685 |doi= 10.1016/S0925-4773(03)00116-3|s2cid=935988 |doi-access=free }}
  • {{cite journal |vauthors=Li S, Weidenfeld J, Morrisey EE |title=Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 809–22 |year= 2004 |pmid= 14701752 |doi=10.1128/MCB.24.2.809-822.2004 | pmc=343786 }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 | author2=Suzuki Y | author3=Nishikawa T | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Hannenhalli S |title=Transcriptional genomics associates FOX transcription factors with human heart failure |journal=Circulation |volume=114 |issue= 12 |pages= 1269–76 |year= 2006 |pmid= 16952980 |doi= 10.1161/CIRCULATIONAHA.106.632430 | author2=Putt ME | author3=Gilmore JM | last4=Wang | first4=J | last5=Parmacek | first5=MS | last6=Epstein | first6=JA | last7=Morrisey | first7=EE | last8=Margulies | first8=KB | last9=Cappola | first9=TP | doi-access=free }}

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{{Transcription factors|g3}}

COVID-19

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