FREM2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.{{cite journal | vauthors = Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ | title = The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis | journal = Proc Natl Acad Sci U S A | volume = 101 | issue = 37 | pages = 13560–5 |date=Sep 2004 | pmid = 15345741 | pmc = 518794 | doi = 10.1073/pnas.0402760101 | bibcode = 2004PNAS..10113560S | doi-access = free }}{{cite web | title = Entrez Gene: FREM2 FRAS1 related extracellular matrix protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=341640}}
This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.
References
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Further reading
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- {{cite journal | vauthors= Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L |title=Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 33 |pages= 11746–50 |year= 2005 |pmid= 16087869 |doi= 10.1073/pnas.0505404102 | pmc= 1183448 |bibcode=2005PNAS..10211746T |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi= 10.1073/pnas.97.7.3491| pmc=16267 |bibcode=2000PNAS...97.3491D |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Dunham A, Matthews LH, Burton J |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |bibcode=2004Natur.428..522D |display-authors=etal}}
- {{cite journal | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 |display-authors=etal}}
- {{cite journal | vauthors=Jadeja S, Smyth I, Pitera JE |title=Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. |journal=Nat. Genet. |volume=37 |issue= 5 |pages= 520–5 |year= 2005 |pmid= 15838507 |doi= 10.1038/ng1549 |s2cid=7666665 |display-authors=etal}}
- {{cite journal | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 |display-authors=etal}}
- {{cite journal | vauthors=Kiyozumi D, Sugimoto N, Sekiguchi K |title=Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 32 |pages= 11981–6 |year= 2006 |pmid= 16880404 |doi= 10.1073/pnas.0601011103 | pmc=1567684 |bibcode=2006PNAS..10311981K |doi-access=free }}
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{{Fibrous proteins}}
{{gene-13-stub}}