FSTL3
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Follistatin-related protein 3 is a protein that in humans is encoded by the FSTL3 gene.{{cite journal |vauthors=Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R | title = FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders | journal = Oncogene | volume = 16 | issue = 22 | pages = 2949–54 |date=Aug 1998 | pmid = 9671416 | doi = 10.1038/sj.onc.1201807 | s2cid = 10736135 | doi-access = }}{{cite journal |vauthors=Glusman G, Kaur A, Hood L, Rowen L | title = An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution | journal = BMC Evol Biol | volume = 4| pages = 43 |date=Nov 2004 | pmid = 15527507 | pmc = 533870 | doi = 10.1186/1471-2148-4-43 | doi-access = free }}{{cite web | title = Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10272}}
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.{{cite web | title = Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10272}}
References
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Further reading
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- {{cite journal |vauthors=Maguer-Satta V, Rimokh R |title=FLRG, member of the follistatin family, a new player in hematopoiesis. |journal=Mol. Cell. Endocrinol. |volume=225 |issue= 1–2 |pages= 109–18 |year= 2005 |pmid= 15451575 |doi= 10.1016/j.mce.2004.07.009 |s2cid=25430198 }}
- {{cite journal |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |bibcode=2000PNAS...97.3491D |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Tortoriello DV, Sidis Y, Holtzman DA |title=Human follistatin-related protein: a structural homologue of follistatin with nuclear localization |journal=Endocrinology |volume=142 |issue= 8 |pages= 3426–34 |year= 2001 |pmid= 11459787 |doi=10.1210/endo.142.8.8319 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Bartholin L, Maguer-Satta V, Hayette S |title=FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins |journal=Oncogene |volume=20 |issue= 39 |pages= 5409–19 |year= 2001 |pmid= 11571638 |doi= 10.1038/sj.onc.1204720 |s2cid=29503172 |display-authors=etal|doi-access= }}
- {{cite journal |vauthors=Bartholin L, Maguer-Satta V, Hayette S |title=Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function |journal=Oncogene |volume=21 |issue= 14 |pages= 2227–35 |year= 2002 |pmid= 11948405 |doi= 10.1038/sj.onc.1205294 |s2cid=1065429 |display-authors=etal|doi-access= }}
- {{cite journal |vauthors=Hill JJ, Davies MV, Pearson AA |title=The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40735–41 |year= 2002 |pmid= 12194980 |doi= 10.1074/jbc.M206379200 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Liu J, Vänttinen T, Hydén-Granskog C, Voutilainen R |title=Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells |journal=Mol. Hum. Reprod. |volume=8 |issue= 11 |pages= 992–7 |year= 2003 |pmid= 12397211 |doi=10.1093/molehr/8.11.992 |doi-access= }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Maguer-Satta V, Bartholin L, Jeanpierre S |title=Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family |journal=Exp. Cell Res. |volume=282 |issue= 2 |pages= 110–20 |year= 2003 |pmid= 12531697 |doi=10.1016/S0014-4827(02)00013-7 |display-authors=etal}}
- {{cite journal |vauthors=Wang HQ, Takebayashi K, Tsuchida K |title=Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 9 |pages= 4432–9 |year= 2003 |pmid= 12970321 |doi=10.1210/jc.2002-021758 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
- {{cite journal |vauthors=Xia Y, Sidis Y, Schneyer A |title=Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice |journal=Mol. Endocrinol. |volume=18 |issue= 4 |pages= 979–94 |year= 2004 |pmid= 14739256 |doi= 10.1210/me.2003-0364 |doi-access= free }}
- {{cite journal |vauthors=Florio P, Ciarmela P, Toti P |title=Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide |journal=Mol. Cell. Endocrinol. |volume=218 |issue= 1–2 |pages= 129–35 |year= 2004 |pmid= 15130517 |doi= 10.1016/j.mce.2003.12.019 |s2cid=42635058 |display-authors=etal}}
- {{cite journal |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Saito S, Sidis Y, Mukherjee A |title=Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3 |journal=Endocrinology |volume=146 |issue= 12 |pages= 5052–62 |year= 2006 |pmid= 16150905 |doi= 10.1210/en.2005-0833 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Okamoto A, Endo H, Kalionis B |title=IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta |journal=Placenta |volume=27 |issue= 2–3 |pages= 317–21 |year= 2006 |pmid= 16338475 |doi= 10.1016/j.placenta.2004.12.007 |display-authors=etal}}
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External links
- {{UCSC genome browser|FSTL3}}
- {{UCSC gene details|FSTL3}}
{{gene-19-stub}}