FUT1
{{Short description|Protein and coding gene in humans}}
{{Infobox_gene}}
Galactoside 2-alpha-L-fucosyltransferase 1 is an enzyme that in humans is encoded by the FUT1 gene.{{cite web | title = Entrez Gene: FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2523}}
The enzyme is involved in the synthesis of the H antigen.
References
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Further reading
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- {{cite journal | vauthors = Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gérard G, Oriol R | title = The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9 | journal = Annals of Human Genetics | volume = 55 | issue = Pt 3 | pages = 225–33 | date = July 1991 | pmid = 1763885 | doi = 10.1111/j.1469-1809.1991.tb00417.x | s2cid = 30777695 }}
- {{cite journal | vauthors = Larsen RD, Ernst LK, Nair RP, Lowe JB | title = Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 17 | pages = 6674–8 | date = September 1990 | pmid = 2118655 | pmc = 54599 | doi = 10.1073/pnas.87.17.6674 | bibcode = 1990PNAS...87.6674L | doi-access = free }}
- {{cite journal | vauthors = Reguigne-Arnould I, Couillin P, Mollicone R, Fauré S, Fletcher A, Kelly RJ, Lowe JB, Oriol R | title = Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19 | journal = Cytogenetics and Cell Genetics | volume = 71 | issue = 2 | pages = 158–62 | year = 1995 | pmid = 7656588 | doi = 10.1159/000134098 }}
- {{cite journal | vauthors = Bruneau N, Lombardo D | title = Chaperone function of a Grp 94-related protein for folding and transport of the pancreatic bile salt-dependent lipase | journal = The Journal of Biological Chemistry | volume = 270 | issue = 22 | pages = 13524–33 | date = June 1995 | pmid = 7768954 | doi = 10.1074/jbc.270.22.13524 | doi-access = free }}
- {{cite journal | vauthors = Kelly RJ, Ernst LK, Larsen RD, Bryant JG, Robinson JS, Lowe JB | title = Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 13 | pages = 5843–7 | date = June 1994 | pmid = 7912436 | pmc = 44093 | doi = 10.1073/pnas.91.13.5843 | bibcode = 1994PNAS...91.5843K | doi-access = free }}
- {{cite journal | vauthors = Koda Y, Soejima M, Kimura H | title = Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA | journal = The Journal of Biological Chemistry | volume = 272 | issue = 11 | pages = 7501–5 | date = March 1997 | pmid = 9054453 | doi = 10.1074/jbc.272.11.7501 | doi-access = free }}
- {{cite journal | vauthors = Wagner FF, Flegel WA | title = Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles | journal = Transfusion | volume = 37 | issue = 3 | pages = 284–90 | date = March 1997 | pmid = 9122901 | doi = 10.1046/j.1537-2995.1997.37397240210.x | s2cid = 25273202 }}
- {{cite journal | vauthors = Kaneko M, Nishihara S, Shinya N, Kudo T, Iwasaki H, Seno T, Okubo Y, Narimatsu H | title = Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme | journal = Blood | volume = 90 | issue = 2 | pages = 839–49 | date = July 1997 | pmid = 9226185 | doi = 10.1182/blood.V90.2.839| doi-access = free }}
- {{cite journal | vauthors = Koda Y, Soejima M, Johnson PH, Smart E, Kimura H | title = Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system | journal = Biochemical and Biophysical Research Communications | volume = 238 | issue = 1 | pages = 21–5 | date = September 1997 | pmid = 9299444 | doi = 10.1006/bbrc.1997.7232 }}
- {{cite journal | vauthors = Koda Y, Soejima M, Kimura H | title = Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUT1) during differentiation of the human erythroid lineage | journal = European Journal of Biochemistry | volume = 256 | issue = 2 | pages = 379–87 | date = September 1998 | pmid = 9760178 | doi = 10.1046/j.1432-1327.1998.2560379.x }}
- {{cite journal | vauthors = Roos C, Kolmer M, Mattila P, Renkonen R | title = Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3168–75 | date = February 2002 | pmid = 11698403 | doi = 10.1074/jbc.M107927200 | doi-access = free }}
- {{cite journal | vauthors = Yip SP, Chee KY, Chan PY, Chow EY, Wong HF | title = Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified | journal = Vox Sanguinis | volume = 83 | issue = 3 | pages = 258–62 | date = October 2002 | pmid = 12366770 | doi = 10.1046/j.1423-0410.2002.00184.x | hdl = 10397/32501 | s2cid = 37005881 | hdl-access = free }}
- {{cite journal | vauthors = López-Ferrer A, de Bolós C | title = The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins | journal = Glycoconjugate Journal | volume = 19 | issue = 1 | pages = 13–21 | date = January 2002 | pmid = 12652076 | doi = 10.1023/A:1022576712961 | s2cid = 13065601 }}
- {{cite journal | vauthors = Shi S, Stanley P | title = Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 9 | pages = 5234–9 | date = April 2003 | pmid = 12697902 | pmc = 154328 | doi = 10.1073/pnas.0831126100 | bibcode = 2003PNAS..100.5234S | doi-access = free }}
- {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}
- {{cite journal | vauthors = Guo ZH, Xiang D, Zhu ZY, Wang JL, Zhang JM, Liu X, Shen W, Chen HP | title = [Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China] | journal = Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics | volume = 21 | issue = 5 | pages = 417–21 | date = October 2004 | pmid = 15476160 }}
- {{cite journal | vauthors = Yan L, Zhu F, Xu X, Hong X, Lv Q | title = Molecular basis for para-Bombay phenotypes in Chinese persons, including a novel nonfunctional FUT1 allele | journal = Transfusion | volume = 45 | issue = 5 | pages = 725–30 | date = May 2005 | pmid = 15847661 | doi = 10.1111/j.1537-2995.2005.04305.x | s2cid = 21841537 }}
- {{cite journal | vauthors = Mejías-Luque R, López-Ferrer A, Garrido M, Fabra A, de Bolós C | title = Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1 | journal = Cancer Science | volume = 98 | issue = 7 | pages = 1000–5 | date = July 2007 | pmid = 17459061 | doi = 10.1111/j.1349-7006.2007.00484.x | s2cid = 24079329 | doi-access = free | pmc = 11159511 }}
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{{Glycosyltransferases}}
{{gene-19-stub}}