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FUT6

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.{{cite journal |vauthors=Koszdin KL, Bowen BR | title = The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand | journal = Biochem Biophys Res Commun | volume = 187 | issue = 1 | pages = 152–7 |date=Oct 1992 | pmid = 1520296 | doi =10.1016/S0006-291X(05)81472-X }}{{cite journal | vauthors = McCurley RS, ((Recinos A III)), Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW | title = Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21 | journal = Genomics | volume = 26 | issue = 1 | pages = 142–6 |date=Jul 1995 | pmid = 7782074 | doi =10.1016/0888-7543(95)80094-3 }}{{cite web | title = Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2528}}

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM]{{cite web | title = Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2528}}

References

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Further reading

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  • {{cite journal |vauthors=Weston BW, Smith PL, Kelly RJ, Lowe JB |title=Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. |journal=J. Biol. Chem. |volume=267 |issue= 34 |pages= 24575–84 |year= 1992 |doi=10.1016/S0021-9258(18)35803-4 |pmid= 1339443 |doi-access=free }}
  • {{cite journal |vauthors=Cameron HS, Szczepaniak D, Weston BW |title=Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 20112–22 |year= 1995 |pmid= 7650030 |doi=10.1074/jbc.270.34.20112 |doi-access=free }}
  • {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal |vauthors=Mollicone R, Reguigne I, Fletcher A |title=Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12662–71 |year= 1994 |doi=10.1016/S0021-9258(18)99927-8 |pmid= 8175676 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
  • {{cite journal |vauthors=Borsig L, Imbach T, Höchli M, Berger EG |title=alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles. |journal=Glycobiology |volume=9 |issue= 11 |pages= 1273–80 |year= 2000 |pmid= 10536043 |doi=10.1093/glycob/9.11.1273 |doi-access=free }}
  • {{cite journal |vauthors=Schnyder-Candrian S, Borsig L, Moser R, Berger EG |title=Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8369–74 |year= 2000 |pmid= 10900002 |doi=10.1073/pnas.97.15.8369 | pmc=26954 |bibcode=2000PNAS...97.8369S |doi-access=free }}
  • {{cite journal |vauthors=Kamińska J, Musielak M, Nowicka A |title=Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase. |journal=Biochimie |volume=83 |issue= 8 |pages= 739–42 |year= 2001 |pmid= 11530205 |doi=10.1016/S0300-9084(01)01306-2 |display-authors=etal}}
  • {{cite journal |vauthors=Roos C, Kolmer M, Mattila P, Renkonen R |title=Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3168–75 |year= 2002 |pmid= 11698403 |doi= 10.1074/jbc.M107927200 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Kanoh A, Ota M, Narimatsu H, Irimura T |title=Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 3 |pages= 896–901 |year= 2003 |pmid= 12670495 |doi=10.1016/S0006-291X(03)00420-0 }}
  • {{cite journal |vauthors=Martinez-Duncker I, Michalski JC, Bauvy C |title=Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis. |journal=Glycobiology |volume=14 |issue= 1 |pages= 13–25 |year= 2004 |pmid= 14514715 |doi= 10.1093/glycob/cwh006 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
  • {{cite journal |vauthors=Higai K, Miyazaki N, Azuma Y, Matsumoto K |title=Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene. |journal=FEBS Lett. |volume=580 |issue= 26 |pages= 6069–75 |year= 2007 |pmid= 17054948 |doi= 10.1016/j.febslet.2006.09.073 |s2cid=9731951 |doi-access= }}

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{{Glycosyltransferases}}

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