FXR2

The protein encoded by this gene is an RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.

FXR2 has been shown to interact with:

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• CYFIP2,{{cite journal | vauthors = Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL | title = A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 15 | pages = 8844–9 | date = Jul 2001 | pmid = 11438699 | pmc = 37523 | doi = 10.1073/pnas.151231598 | bibcode = 2001PNAS...98.8844S | doi-access = free }}
• FMR1,{{cite journal | vauthors = Ceman S, Brown V, Warren ST | title = Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex | journal = Molecular and Cellular Biology | volume = 19 | issue = 12 | pages = 7925–32 | date = Dec 1999 | pmid = 10567518 | pmc = 84877 | doi = 10.1128/mcb.19.12.7925}}
• FXR1,{{cite journal | vauthors = Siomi MC, Zhang Y, Siomi H, Dreyfuss G | title = Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them | journal = Molecular and Cellular Biology | volume = 16 | issue = 7 | pages = 3825–32 | date = Jul 1996 | pmid = 8668200 | pmc = 231379 | doi = 10.1128/mcb.16.7.3825}} and
• LCMT1.{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network|author-link30=Huda Zoghbi | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R| s2cid = 4427026}}

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{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Siomi MC, Zhang Y, Siomi H, Dreyfuss G | title = Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them | journal = Molecular and Cellular Biology | volume = 16 | issue = 7 | pages = 3825–32 | date = Jul 1996 | pmid = 8668200 | pmc = 231379 | doi = 10.1128/mcb.16.7.3825}}
• {{cite journal | vauthors = Joseph DR | title = The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap | journal = Steroids | volume = 63 | issue = 1 | pages = 2–4 | date = Jan 1998 | pmid = 9437788 | doi = 10.1016/S0039-128X(97)00087-1 | s2cid = 12825993 }}
• {{cite journal | vauthors = Tamanini F, Bontekoe C, Bakker CE, van Unen L, Anar B, Willemsen R, Yoshida M, Galjaard H, Oostra BA, Hoogeveen AT | title = Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations | journal = Human Molecular Genetics | volume = 8 | issue = 5 | pages = 863–9 | date = May 1999 | pmid = 10196376 | doi = 10.1093/hmg/8.5.863 | doi-access = free | hdl = 1765/9073 | hdl-access = free }}
• {{cite journal | vauthors = Bardoni B, Schenck A, Mandel JL | title = A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein | journal = Human Molecular Genetics | volume = 8 | issue = 13 | pages = 2557–66 | date = Dec 1999 | pmid = 10556305 | doi = 10.1093/hmg/8.13.2557 | doi-access = free }}
• {{cite journal | vauthors = Ceman S, Brown V, Warren ST | title = Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex | journal = Molecular and Cellular Biology | volume = 19 | issue = 12 | pages = 7925–32 | date = Dec 1999 | pmid = 10567518 | pmc = 84877 | doi = 10.1128/mcb.19.12.7925}}
• {{cite journal | vauthors = Cousin P, Billotte J, Chaubert P, Shaw P | title = Physical map of 17p13 and the genes adjacent to p53 | journal = Genomics | volume = 63 | issue = 1 | pages = 60–8 | date = Jan 2000 | pmid = 10662545 | doi = 10.1006/geno.1999.6062 }}
• {{cite journal | vauthors = Tamanini F, Kirkpatrick LL, Schonkeren J, van Unen L, Bontekoe C, Bakker C, Nelson DL, Galjaard H, Oostra BA, Hoogeveen AT | title = The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins | journal = Human Molecular Genetics | volume = 9 | issue = 10 | pages = 1487–93 | date = Jun 2000 | pmid = 10888599 | doi = 10.1093/hmg/9.10.1487 | doi-access = free | hdl = 1765/9408 | hdl-access = free }}
• {{cite journal | vauthors = Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL | title = A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 15 | pages = 8844–9 | date = Jul 2001 | pmid = 11438699 | pmc = 37523 | doi = 10.1073/pnas.151231598 | bibcode = 2001PNAS...98.8844S | doi-access = free }}
• {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | date = May 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
• {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = Jan 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
• {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
• {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 | doi-access = free }}
• {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | doi-access = free }}
• {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}

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