FXYD3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
FXYD domain-containing ion transport regulator 3 is a protein that in humans is encoded by the FXYD3 gene.{{cite journal | vauthors = Morrison BW, Moorman JR, Kowdley GC, Kobayashi YM, Jones LR, Leder P | title = Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes | journal = The Journal of Biological Chemistry | volume = 270 | issue = 5 | pages = 2176–82 | date = Feb 1995 | pmid = 7836447 | doi = 10.1074/jbc.270.5.2176 | doi-access = free }}{{cite journal | vauthors = Sweadner KJ, Rael E | title = The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression | journal = Genomics | volume = 68 | issue = 1 | pages = 41–56 | date = Aug 2000 | pmid = 10950925 | doi = 10.1006/geno.2000.6274 }}{{cite web | title = Entrez Gene: FXYD3 FXYD domain containing ion transport regulator 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5349}}
Function
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene may function as a chloride channel or as a chloride channel regulator. Two transcript variants encode two different isoforms of the protein; in addition, transcripts utilizing alternative polyA signals have been described in the literature.
References
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Further reading
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- {{cite journal | vauthors = Crowell KJ, Franzin CM, Koltay A, Lee S, Lucchese AM, Snyder BC, Marassi FM | title = Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers | journal = Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | volume = 1645 | issue = 1 | pages = 15–21 | date = Jan 2003 | pmid = 12535606 | pmc = 2917601 | doi = 10.1016/S1570-9639(02)00473-9 }}
- {{cite journal | vauthors = Grzmil M, Voigt S, Thelen P, Hemmerlein B, Helmke K, Burfeind P | title = Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells | journal = International Journal of Oncology | volume = 24 | issue = 1 | pages = 97–105 | date = Jan 2004 | pmid = 14654946 | doi = 10.3892/ijo.24.1.97 }}
- {{cite journal | vauthors = Kayed H, Kleeff J, Kolb A, Ketterer K, Keleg S, Felix K, Giese T, Penzel R, Zentgraf H, Büchler MW, Korc M, Friess H | title = FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth | journal = International Journal of Cancer | volume = 118 | issue = 1 | pages = 43–54 | date = Jan 2006 | pmid = 16003754 | doi = 10.1002/ijc.21257 | s2cid = 8644783 | doi-access = free }}
- {{cite journal | vauthors = Franzin CM, Yu J, Thai K, Choi J, Marassi FM | title = Correlation of gene and protein structures in the FXYD family proteins | journal = Journal of Molecular Biology | volume = 354 | issue = 4 | pages = 743–50 | date = Dec 2005 | pmid = 16288923 | pmc = 2907130 | doi = 10.1016/j.jmb.2005.10.018 }}
- {{cite journal | vauthors = Bibert S, Roy S, Schaer D, Felley-Bosco E, Geering K | title = Structural and functional properties of two human FXYD3 (Mat-8) isoforms | journal = The Journal of Biological Chemistry | volume = 281 | issue = 51 | pages = 39142–51 | date = Dec 2006 | pmid = 17077088 | doi = 10.1074/jbc.M605221200 | doi-access = free }}
- {{cite journal | vauthors = Arimochi J, Ohashi-Kobayashi A, Maeda M | title = Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells | journal = Biological & Pharmaceutical Bulletin | volume = 30 | issue = 4 | pages = 648–54 | date = Apr 2007 | pmid = 17409496 | doi = 10.1248/bpb.30.648 | doi-access = free }}
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