Fabrizio Chiti
{{Use dmy dates|date=October 2019}}
{{short description|Italian biochemist}}
{{Infobox scientist
|name = Fabrizio Chiti
|image = File:Fabrizio Chiti in 2015.jpg
|caption = Fabrizio Chiti in 2015
|birth_date = {{birth date and age|df=y|1971|7|7}}
|birth_place = Florence, Italy
|death_place =
|ethnicity =
|fields = Biophysics, Biochemistry
|workplaces = Department of Experimental and Clinical Biomedical Sciences, University of Florence
|alma_mater = Biological Sciences, University of Florence, Italy(E.N.S., 1995)
|doctoral_advisor = Chris Dobson
|academic_advisors = Giampietro Ramponi, Chris Dobson
|doctoral_students =
|notable_students =
|known_for = Protein aggregation and amyloid
|influences =
|influenced =
|awards = {{Plainlist|
- Jean-Francois LeFèvre Lecture at the Ecole Supérieure de Biotechnologie de Strasbourg (ESBS) (2003)
- Member of the Academia Europaea (2015)
- EMBO Young Investigator (2005)
- Roncaglia-Mari Award, Accademia Nazionale dei Lincei(2010)}}
|signature =
|footnotes =
| website = {{URL|www.sbsc.unifi.it/vp-209-gruppo-chiti.html}}
}}
Fabrizio Chiti (born in Florence, 7 July 1971) is an Italian biochemist noted for his work on Protein aggregation and amyloid.{{Cite web|url= https://www2.scopus.com/authid/detail.uri?authorId=7004045049|title=Citation metrics, Scopus|access-date=5 October 2019}}
Education
Chiti is a graduate in Biological Sciences of the University of Florence (Italy).{{Cite web | url= https://www.unifi.it/p-doc2-2018-0-A-2b333c323627-1.html| title=CV details on the official page of the University of Florence}} He attained a PhD degree (D.Phil) in Chemistry in 2000 at the University of Oxford in UK. He then worked as a postdoctoral researcher at the University of Florence, Italy, with Giampietro Ramponi as a supervisor (2000–2002) and at the University of Cambridge, UK, under the supervision of Chris Dobson (2002).
Research and career
He was appointed as an Associate (2002) and then Full Professor (2010) at the University of Florence in Biochemistry.
Chiti provided contributions in the field of misfolding and aggregation, particularly in the field of amyloid He rationalized how amino acid mutations induce protein aggregation and edited an equation to predict the effect of mutations on the aggregation of an unfolded protein,{{cite journal | vauthors = Chiti F, Taddei N, Bucciantini M, White P, Ramponi G, Dobson CM| title = Mutational analysis of the propensity for amyloid formation by a globular protein| journal = EMBO Journal| volume = 19 | pages = 1441–9 | date = 3 April 2000 | issue = 7| pmid = 10747012| doi = 10.1093/emboj/19.7.1441| pmc = 310213}}{{cite journal | vauthors = Chiti F, Stefani M, Taddei N, Ramponi G, Dobson CM| title = Rationalization of the effects of mutations on peptide and protein aggregation rates.| journal = Nature| volume = 424 | pages = 805–8 | date = 14 August 2003 | issue = 6950| doi = 10.1038/nature01891| pmid = 12917692| bibcode = 2003Natur.424..805C| s2cid = 4421180}} which led to a search by many investigators of algorithms with predictive power on essential aspects of protein aggregation. He also correlated the toxicities of abnormal protein oligomers with specific structural properties of them.{{cite journal | vauthors = Campioni S, Mannini B, Zampagni M, Pensalfini A, Parrini C, Evangelisti E, Relini A, Stefani M, Dobson CM, Cecchi C, Chiti F| title = A causative link between the structure of aberrant protein oligomers and their toxicity| journal = Nature Chemical Biology| volume = 6 | pages = 140–7| date = February 2010 | issue = 2| pmid = 20081829| doi = 10.1038/nchembio.283| hdl = 2158/382930| s2cid = 43311039| hdl-access = free}} His 2006 review with Chris Dobson on protein misfolding, amyloid formation and human disease,{{cite journal | vauthors = Chiti F, Dobson CM| title = Protein misfolding, functional amyloid, and human disease| journal = Annual Review of Biochemistry| volume = 75 | pages = 333–66 | date = 5 June 2006 | doi = 10.1146/annurev.biochem.75.101304.123901| pmid = 16756495| s2cid = 23797549}} later updated as a new report,{{cite journal | vauthors = Chiti F, Dobson CM | title = Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.| journal = Annual Review of Biochemistry| volume = 86 | pages = 26–68 | date = 20 June 2017 | pmid = 28498720| doi = 10.1146/annurev-biochem-061516-045115| hdl = 2158/1117236| hdl-access = free}} is a reference paper in the field of amyloid and received, as of October 2019, more than four thousands citations in scientific publications.{{Cite web | url= https://scholar.google.com/scholar?hl=it&as_sdt=0%2C5&q=fabrizio+chiti&btnG=&oq=chiti| title=Citations to Fabrizio Chiti, source Google Scholars}}
Awards and honors
- Election to EMBO Young Investigator program, European Molecular Biology Organization, 2005{{Cite web | url= https://yip-search.embo.org/#/yip/2444| title=Membership to EMBO Young Investigator Program to Fabrizio Chiti}}
- Election to member of Academia Europaea, 2015{{Cite web | url= https://www.ae-info.org/ae/Member/Chiti_Fabrizio| title=Membership to Academia Europaea to Fabrizio Chiti}}
- Jean-Francois LeFèvre Lecture, École supérieure de biotechnologie Strasbourg, 2003{{Cite web|url= https://www.unifi.it/p-doc2-2018-0-A-2b333c323627-1.html| title= Quotation to Jean-Francois LeFèvre Lecture}}
- Maria Teresa Messori Roncaglia ed Eugenio Mari Award, Accademia Nazionale dei Lincei, 2010{{Cite web | url= https://www.lincei.it/it/premi-borse| title=List of Awards at Academia Nazionale dei Lincei}}
References
{{Reflist|35em}}
External links
{{Wikiquote}}
- [https://www.unifi.it/p-doc2-2018-0-A-2b333c323627-1.html Fabrizio Chiti's homepage at University of Florence]
- [https://www.sbsc.unifi.it/vp-209-gruppo-chiti.html Fabrizio Chiti's laboratory at University of Florence]
- [https://www.sbsc.unifi.it/ Department of Biomedical Experimental and Clinical Sciences at University of Florence]
{{DEFAULTSORT:Chiti, Fabrizio}}
Category:Members of Academia Europaea