Factitious airs#carbon dioxide

Robert Boyle coined the term Factitious Air upon isolating hydrogen in 1670. Henry Cavendish (1731–1810) used the term "factitious air" to refer to "any kind of air which is contained in other bodies in an unelastic state, and is produced from thence by art".

An archaic definition from 1747 for the production of factitious air was defined as being caused by: "1- by flow Degrees from Putrefactions and Fermentations of all Kinds; or 2- more expeditiously by some Sorts of chymical Dissolutions of Bodies; or 3- and lastly, almost instantaneously by the Explosion of Gunpowder, and the Mixture or some Kinds of Bodies. Thus, if Paste or Dough with Leaven be placed in an exhausted Receiver, it will, after some Time, by Fermentation, produce a considerable quantity of Air, which will appear very plainly by the Sinking the Quicksilver in the Gage. Thus also any Animal or Vegetable Substance, putrifying in Vacuo, will produce the same Effect."{{Cite book|last=Martin|first=B|url=https://books.google.com/books?id=B8s2AAAAMAAJ&q=factitious+air&pg=PP31|title=Philosophia Britannica: Or, A New & Comprehensive System of the Newtonian Philosophy, Astronomy & Geomgraphy: In a Course of Twelve Lectures, with Notes, Containing the Physical, Mechanical, Geometrical, & Experimental Proofs & Illustrations of All the Principal Propositions in Every Branch of Natural Science. Also a Particular Account of the Invention ... of All the Considerable Instruments, Engines, & Machines ...|date=1747|publisher=C. Micklewright & Company|pages=3|language=en}}

There are significant inconsistencies in the archaic nomenclature due to the limited knowledge of chemistry and primitive analytical technology of the era (i.e. based on the chemistry, it is clear the terms were mistakenly assigned to more than one gas by different investigators). Furthermore, in most cases the gases were not pure.

Names used for factitious airs may have included:{{citation needed|date=March 2021}}

• ammonical gas{{Cite book|last=Cadell Jr.|first=T|url=https://books.google.com/books?id=q74CAAAAYAAJ&q=carbonic&pg=PA3|title=Minutes of the Society for Philosophical Experiments and Conversations|date=1795|publisher=|location=London|pages=31, 35|language=en}}
• ammoniac{{Cite book|last=Nisbet|first=William|url=https://books.google.com/books?id=61kUAAAAQAAJ&dq=hydrocarbonate%2C+heavy+inflammable+air&pg=PA380|title=A general dictionary of chemistry|date=1805|pages=377|language=en}}
• volatile alkali{{Cite book|last=Cooley|first=AJ|url=https://books.google.com/books?id=jG4DAAAAYAAJ&q=fixed+air|title=A Cyclopaedia of Practical Receipts: And Collateral Information in the Arts, Manufacutres, and Trades, Including Medicine, Pharmacy, and Domestic Economy|date=1845|publisher=John Churchill|pages=252|language=en}}
• alkaline air
• gaseous ammonia
• azoturetted hydrogen

Source:{{Cite journal|last=Foregger|first=R|title=Joseph Black and the Identification of Carbon Dioxide|date=March 1957|url=https://pubs.asahq.org/anesthesiology/article/18/2/257/15042/JOSEPH-BLACK-AND-THE-IDENTIFICATION-OF-CARBON|journal=Anesthesiology|language=en|volume=18|issue=2|pages=257–264|doi=10.1097/00000542-195703000-00011|pmid=13411612|s2cid=11759504|issn=0003-3022|doi-access=free}}

Fixed air, or fixible air, is an ancient term for carbon dioxide

Joseph Priestley credited Joseph Black for discovering and coining "fixed air", which was thought to exist in a fixed state in alkaline salts, chalk, and other calcareous substances. Black considered substances containing fixed air to be "mild", and upon expulsion of the gas by heating the resulting state is "caustic" by corroding or burning plants and animals (e.g. {{CO2}} released by chalk upon decomposition to calcium oxide). In other words, the fixed air (also known as fixible air) was thought to be fixated within a corrosive molecule.

Priestley likewise credited the discovery of fixed air to contributions from several scientists including: David Macbride, John Pringle, William Brownrigg (regarded carbonated water to have an acidulous taste), Stephen Hales, and many others.{{Cite book|last=Priestley|first=J|url=https://books.google.com/books?id=mLlBAQAAMAAJ&q=fixed+air+history&pg=PA4|title=Directions for Impregnating Water with Fixed Air: In Order to Communicate to it the Peculiar Spirit and Virtues of Pyrmont Water, and Other Mineral Waters of a Similar Nature|date=1774|publisher=J. Johnson|language=en}}{{Cite book|last1=Brande|first1=W. T.|url=https://books.google.com/books?id=CYYDAAAAQAAJ&q=scientist+lane+fixed+air&pg=PA431|title=A Dictionary of Science, Literature, & Art: Comprising the Definitions and Derivations of the Scientific Terms in General Use, Together with the History and Descriptions of the Scientific Principles of Nearly Every Branch of Human Knowledge|last2=Cox|first2=George William|date=1865|publisher=Longmans, Green|pages=426|language=en}}{{Cite book|url=https://books.google.com/books?id=2wA_AQAAMAAJ&q=scientist+lane+fixed+air&pg=PA15793|title=Scientific American Supplement: "History of Soda Water"|date=1894|publisher=Munn and Company|pages=15793|language=en}}

Henry Cavendish provided a definition: "By fixed air, I mean that particular species of factitious air, which is separated from alkaline substances by solution in acids or by calcination".{{cite journal | vauthors = Cavendish H |title=XIX. Three papers, containing experiments on factitious air |journal=Philosophical Transactions of the Royal Society of London |date=31 December 1766 |volume=56 |pages=141–184 |doi=10.1098/rstl.1766.0019|s2cid=186209704 |doi-access=free }} Cavendish essentially defined potassium oxide or calcium oxide as a base, which can contain a fixated air within its composition, setting the stage for the historical definition of carbonate.

Source:{{Cite book|last=Archer|first=C|url=https://books.google.com/books?id=3WJpAAAAcAAJ&q=fixed&pg=PA1|title=Miscellaneous Observations on the Effects of Oxygen on the animal and vegetable systems, etc. pt. 1|date=1798|publisher=R. Cruttwell|pages=34, 99, 137|language=en}}

According to Claude Louis Berthollet, "What has long been called fixed, or fixible air, being really an acid in the state of gas, has of late received several new denominations. It has been called aerial acid, as existing very readily in the state of air, or more properly of gas, and plentifully in the atmosphere. The chalky acid, as procurable in large quantities from chalk, or other mild calcareous substances. The name given to it in this essay is derived from the knowledge of its composition, as lately ascertained by the French Chemists to consist of the elementary part of charcoal, named charbone, or char, united with oxygen, or the acidifying principle. Hence it is called, with strict propriety, carbonic acid in general; carbonic acid gas when in the aerial form; and carbonic acid liquor when combined with or dissolved in water."{{Cite book|last=Berthollet|first=C. L.|url=https://books.google.com/books?id=Bb9lAAAAcAAJ&q=carbonic&pg=PA1|title=Essay on the New Method of Bleaching, by means of oxygenated muriatic acid; with an account of the nature, preparation, and properties, of that acid.|date=1790|publisher=Trustees of the Linen&Hempen Manufacture|pages=12–13, 43|language=en}}

By French Chemists, Berthollet is generally referring to Lavoisier's oxidation discoveries.{{Cite web|last=Foell|first=H|title=History of Carbon|url=https://www.tf.uni-kiel.de/matwis/amat/iss/kap_4/advanced/t4_2_1.html|access-date=2021-11-01|website=University of Kiel}} The name oxygen is derived from Greek with oxy meaning acid, and gene to mean forming/expression, therefore carbonic acid is simply the union of carbon with oxygen (Laviosier's original degrees of oxidation could not fit the concept of carbon monoxide as it was based on diamond, graphite, coal and carbonic acid)

Carbonate was defined as "a compound formed by the union of carbonic acid with an earth, alkali, or metallic oxide [...] they are distinguished by the property of effervescing on the addition of an acid" The definition expands upon fixed air being fixated within carbonate to suggest carbonic acid is a constituent of carbonate, therefore in the ancient language the suffix "-ic acid" and "-ate" were not interchangeable.

The modern definition is similar, although equipped with the molecular knowledge of carbonate's structure and reassignment of the meaning of carbonic acid from CO₂ to the H₂CO₃ molecule, "Carbonates are the salts of carbonic acids. They form when a positively charged metal ion comes into contact with the oxygen atoms of the carbonate ion."{{Cite web|title=Carbon Oxides and Carbonates {{!}} Introduction to Chemistry|url=https://courses.lumenlearning.com/introchem/chapter/carbon-oxides-and-carbonates/|access-date=2021-11-10|website=courses.lumenlearning.com}}

Bicarbonate, originally known as bi-carbonate of potash, was coined by William Hyde Wollaston in 1814 based on hydrocarbonate's potential to release two molar equivalents of carbon dioxide (referred to as carbonic acid at the time) as released by both potassium hydrocarbonate (initially known as carbonate of potash, suggested to become bicarbonate) and potassium carbonate (vaguely known as subcarbonate, suggested to become carbonate) upon formation of potash (potassium oxide{{Cite book|last=Van Slyke|first=L. L.|url=https://books.google.com/books?id=T4ojAQAAIAAJ&q=potassium+oxide+known+as+lime&pg=PA17|title=Bulletin No. 55|publisher=Department of Agriculture|year=1900|pages=17|language=en}}).{{Cite journal|last=Wollaston|first=W. H.|date=December 1814|title=I. A Synoptic scale of chemical equivalents|url=https://royalsocietypublishing.org/doi/10.1098/rstl.1814.0001|journal=Philosophical Transactions of the Royal Society of London|language=en|volume=104|pages=1–22|doi=10.1098/rstl.1814.0001|s2cid=96774986|issn=0261-0523|url-access=subscription}}

Bicarbonates have historically been defined as, "combinations of the bases with the carbonic acid, in which two atoms of the latter are united to one of the former" In other words, potash (potassium oxide) was well-understood to be a caustic base and essentially the core molecule that subsequent chemical nomenclature was built upon. Carbonate of potash (potassium carbonate) must contain a carbonic acid species fixated within potash's alternative composition (see fixed air above). Since "bi-carbonate of potash" liberates a double dose of carbonic acid, to distinguish between the similar substances, the prefix bi- indicates the bi-carbonate of potash (potassium hydrocarbonate) contains twice as much {{CO2}} fixated in this form potash's composition relative to the carbonate of potash. The same ancient logic (prior to the understanding of molecular formulas and reaction stoichiometry) applied to soda, carbonate of soda, and bicarbonate of soda.

The word saleratus, from Latin sal æratus (meaning "aerated salt"), was widely used beginning in the 1840s.{{Cite web|title=Definition of SALERATUS|url=https://www.merriam-webster.com/dictionary/saleratus|access-date=2021-11-10|website=www.merriam-webster.com|language=en}}{{Cite web|last=Perry|first=C|date=November 1996|title=Tiny Bubbles|url=https://www.latimes.com/archives/la-xpm-1996-11-29-fo-4119-story.html|access-date=2021-11-10|website=Los Angeles Times|language=en-US}}

Carbonic acid gas was an ancient term to specify the gaseous state of carbonic acid (synonymous with carbonic acid). It is listed as an alternative name for carbon dioxide in PubChem.{{Cite web|last=PubChem|title=Carbon dioxide|url=https://pubchem.ncbi.nlm.nih.gov/compound/280|access-date=2021-10-23|website=pubchem.ncbi.nlm.nih.gov|language=en}} In 1796 externally applied carbonic acid gas to the epidermis was reported to treat breast cancer; and inhalation treated tuberculosis and other indications.{{Cite book|last=Beddoes|first=T|url=https://books.google.com/books?id=iAg2AQAAMAAJ&dq=carbonic+acid&pg=PA31|title=Considerations on the Medicinal Use, and on the Production of Factitious Airs: Part I. By Thomas Beddoes, M.D. Part II. By James Watt, Engineer|date=1796|publisher=Bulgin and Rosser|pages=10–12, 30, 37, 82|language=en}}

• gas silvestre
• Ancient origin for fixed air by Jan Baptist van Helmont
• Spiritus sylvestris
• aerial acid
• acid of air
• luft-saeure
• carbonic anhydride{{Cite book|last=Cooley|first=AJ|url=https://books.google.com/books?id=u_xAAQAAMAAJ&q=carbonic+oxide|title=Cooley's Cyclopædia of Practical Receipts and Collateral Information in the Arts, Manufactures, Professions, and Trades, Including Medicine, Pharmacy, and Domestic Economy: Designed as a Comprehensive Supplement to the Pharmacopœia and General Book of Reference for the Manufacturer, Tradesman, Amateur, and Heads of Families|date=1897|publisher=D. Appleton|language=en}}
• Gas acide carbonique
• Gas carbonicum
• chalky acid
• acid of chalk
• kriedesaeure
• kohlensaeures gas
• choke-damp
• cretaceous acid{{Cite book|url=https://books.google.com/books?id=_WLwAZvExlQC&q=sulphurated+hydrogene++A+New+English+Dictionary+on+Historical+Principles%3A&pg=PA384|title=The English Encyclopædia: Being a Collection of Treatises, and a Dictionary of Terms, Illustrative of the Arts and Sciences|date=1802|publisher=G. Kearsley ..., sold|pages=384, 411|language=en}}
• Acide mephitique
• Mephitic air
• deutoxide of carbon

{{Further|Gasotransmitter|Carbon monoxide-releasing molecules|Heme oxygenase}}

{{Further|Carboxyhemoglobin|Carbon monoxide|Carbon monoxide poisoning}}

• hydrocarbonate{{Cite book|last=Beddoes|first=T|url=https://books.google.com/books?id=MGdEAQAAMAAJ&q=beddoes+hydrocarbonate&pg=PA385|title=The Analytical Review, Or History of Literature, Domestic and Foreign, on an Enlarged Plan, "Beddoes and Watt on Factitious Airs"|date=1797|pages=385|language=en}}{{Cite book|last=Franke|first=T|url=https://books.google.com/books?id=wT9DAAAAYAAJ&dq=bihydroguret&pg=PA266|title=Technological Dictionary: English-German-French|date=1855|publisher=Kreidel & Niedner|pages=38, 266|language=en}}
• Water gas prepared by passing steam over charcoal/coke. Alternatively prepared from unspecified alcohol and sulphuric acid.{{Cite book|last=Davy|first=Humphry|url=https://books.google.com/books?id=N7E5AAAAcAAJ&q=beddoes+hydrocarbonate&pg=PA382|title=Chemical Researches|date=1800|pages=382|language=en}}
• Hydrocarbonate was recognized to brighten venous blood and compete with oxygen around 1796, although credit is widely awarded to Claude Bernard's work in the mid-1850s.{{Cite book|last=Mellor|first=JW|url=https://books.google.com/books?id=uAhGAQAAMAAJ&dq=carbonic+oxide+woodhouse&pg=PA908|title=Supplement to Mellor's Comprehensive Treatise on Inorganic and Theoretical Chemistry: pt. B1. Boron-Hydrogen compounds|date=1924|publisher=Longmans, Green and Company|pages=456–472|language=en}}
• hydrocarbonous acid{{Cite book|last=Read|first=J|url=https://books.google.com/books?id=Ge4EAAAAQAAJ&dq=hydrocarbonate%2C+heavy+inflammable+air&pg=RA1-PA229|title=An appeal to the medical profession, on the utility of the improved patent syringe, with directions for its several uses, "Dr. Smith's Principles of Forensic Medicine"|date=1824|pages=229|language=en}}
• heavy inflammable air
• carbonated hydrogene
• carbonic oxide / protoxide
• William Cruickshank discovered the composition of carbon monoxide and named it gaseous oxide of carbon.{{Cite book|last=Mellor|first=JW|url=https://books.google.com/books?id=uAhGAQAAMAAJ&dq=carbonic+oxide+woodhouse&pg=PA908|title=Supplement to Mellor's Comprehensive Treatise on Inorganic and Theoretical Chemistry: pt. B1. Boron-Hydrogen compounds, "22. The History of Carbon Monoxide"|date=1924|publisher=Longmans, Green and Company|pages=907|language=en}}{{Cite book|last=Harrington|url=https://books.google.com/books?id=0zMsbuLpNnMC&dq=hydrocarbonate%2C+heavy+inflammable+air&pg=PA520|title=The Gentleman's Magazine|date=1801|publisher=E. Cave|pages=519–521|language=en}}{{Cite book|last=Murray|first=J|url=https://books.google.com/books?id=bZw-AAAAYAAJ&dq=heavy+inflammable+air+woodhouse&pg=PA333|title=A System of Chemistry: In Four Volumes|date=1819|publisher=F. Pillans; and for Longman, Hurst, Rees, Orme & Brown, London|pages=333–334|language=en}} Cruickshank recognized water and hydrogen were not a constituent of the combustible base which contained the same ingredients as carbonic acid, although containing less oxygen.
• Carbonic oxide was identified in the intestine of cattle in the 1800s, marking a trace origin for endogenous carbon monoxide.{{Cite book|last=Gmelin|first=L|url=https://books.google.com/books?id=aokMAAAAYAAJ&dq=carbonic+oxide+woodhouse&pg=PA82|title=Hand-book of Chemistry: Inorganic chemistry|date=1849|publisher=Cavendish Society|pages=87|language=en}}
• carbonous oxyd{{Cite book|last1=Aikin|first1=A|url=https://books.google.com/books?id=VLAiAQAAMAAJ&dq=hydrocarbonate%2C+heavy+inflammable+air&pg=PA244|title=A Dictionary of Chemistry and Mineralogy: With an Account of the Processes Employed in Many of the Most Important Chemical Manufactures. To which are Added a Description of Chemical Apparatus, and Various Useful Tables of Weights and Measures, Chemical Instruments ... Illustrated with 15 Engravings|last2=Aikin|first2=CR|date=1807|publisher=J. and A. Arch|pages=244|language=en}}
• The name carbonous oxyd relative to carbonic acid was once considered analogous to nitrous oxide to nitric acid based on the oxide not having sufficient oxygen to form the acid.

Hydrogen was initially thought to be toxic based on experiments by Lavoisier, however, the purity of the hydrogen was taken into question when later experiments discovered hydrogen to effectively treat measles in the 1790s.

• factitious air (Boyle)
• hydrogene – means "water former" from hydro- and gene-{{Cite web|title=Lavoisier's Elements of Chemistry|url=https://web.lemoyne.edu/~giunta/ea/lavprefann.html|access-date=2021-10-23|website=web.lemoyne.edu}}
• inflammable air
• inflammable gas
• base of inflammable air
• zincic inflammable air
• martial inflammable air

• sulphurated hydrogene
• therapeutic application of H2S for gastrointestinal disorders dates as early as 1806{{Cite journal|last=Forbes|first=W|date=January 1806|title=On the Use of Sulphurated Hydrogen in Stomachic Complaints|journal=Edinburgh Medical and Surgical Journal|volume=2|issue=5|pages=9–10|issn=0963-4932|pmc=5761423|pmid=30330024}}
• hepatic air{{Cite book|last1=Murray|first1=JAH|url=https://books.google.com/books?id=YwiBKmz97ecC&q=sulphurated+hydrogene&pg=PA487|title=A New English Dictionary on Historical Principles: Founded Mainly on the Materials Collected by the Philological Society|last2=Bradley|first2=H|last3=Craigie|first3=Sir WA|last4=Onions|first4=CT|date=1901|publisher=Clarendon Press|pages=487|language=en}}

• marsh gas/air
• carburetted hydrogen
• light carburetted hydrogen
• heavy inflammable air
• dicarburet of hydrogen
• fire-damp
• gas of the acetates{{Cite book|last=Cooley|first=AJ|url=https://books.google.com/books?id=z5cAAAAAMAAJ&q=sulphurated&pg=PA1069|title=Cooley's Cyclopaedia of Practical Receipts and Collateral Information in the Arts, Manufactures, Professions, and Trades, Including Medicine, Pharmacy and Domestic Economy: Designed as a Comprehensive Supplement to the Pharmacopœoeia and General Book of Reference for the Manufacturer, Tradesman, Amateur, and Heads of Families|date=1872|publisher=J. & A. Churchill|language=en}}

• azotic air
• azote – means lifeless, or a-zote for "not life",{{Cite journal|last=Ringnes|first=Vivi|date=September 1989|title=Origin of the names of chemical elements|url=https://pubs.acs.org/doi/pdf/10.1021/ed066p731|journal=Journal of Chemical Education|volume=66|issue=9|pages=731|doi=10.1021/ed066p731|bibcode=1989JChEd..66..731R|issn=0021-9584|url-access=subscription}} generally regarded as the solid constituent whereas azotic gas was the gaseous form.
• phlogisticated air
• atmospherical memphitic gas
• mephitis
• nitrogene
• base of mephitis
• stickstoffgas

• factitious air (Davy)
• dephlogisticated nitrous air{{Cite book|last=Barker|first=George T.|url=https://books.google.com/books?id=axU3AQAAMAAJ&q=nitrous+oxide+known+as&pg=PA7|title=Instructions in the Preparation, Administration, and Properties of Nitrous Oxide, Protoxide of Nitrogen, Or Laughing Gas|date=1870|publisher=Rubencame and Barker|pages=9|language=en}}
• protoxide of nitrogen
• hypo-nitrous oxide{{Cite book|last=Guilford|first=S. H.|url=https://books.google.com/books?id=57YNAAAAYAAJ&q=nitrous+oxide+known+as&pg=PA1|title=Nitrous Oxide; Its Properties, Method of Administration and Effects|date=1887|publisher=Spangler & Davis|pages=5|language=en}}
• gaseous oxide of azote{{Cite book|last=Warren|first=E|url=https://books.google.com/books?id=dAc9AAAAcAAJ&q=known+to+chemists+gaseous+oxide&pg=PA5|title=Some Account of the Letheon: Or, Who is the Discoverer?|date=1847|publisher=Dutton and Wentworth|pages=28|language=en}}

Blood has been understood to absorb and deliver oxygen since the mid-1790s.

• vital air
• highly respirable air
• pure air
• phosoxygen{{Cite book|last=Beddoes|first=T|url=https://books.google.com/books?id=d3EFAAAAQAAJ&q=carbonic+acid+gas|title=Contributions to Physical and Medical Knowledge: Principally from the West of England|date=1799|publisher=Biggs & Cottle|pages=60|language=en}}
• dephlogisticated air
• empyreal air
• base of vital air
• oxy-gene means acid-former or acid-expression, once thought all acids contained oxygen.

• animal inflammable air

The study of these airs interfaced with phlogiston theory.

The therapeutic potential of factitious airs were widely investigated with significant contributions by Thomas Beddoes, James Watt, James Lind, Humphry Davy, and others at the Pneumatic Institution.{{cite journal | vauthors = Levere TH | title = Dr. Thomas Beddoes and the establishment of his pneumatic institution: a tale of three presidents | journal = Notes and Records of the Royal Society of London | volume = 32 | issue = 1 | pages = 41–9 | date = July 1977 | pmid = 11615622 | doi = 10.1098/rsnr.1977.0005 | s2cid = 27322059 }}{{Cite journal|last1=Hopper|first1=Christopher P.|last2=Zambrana|first2=Paige N.|last3=Goebel|first3=Ulrich|last4=Wollborn|first4=Jakob|date=June 2021|title=A brief history of carbon monoxide and its therapeutic origins|url=https://linkinghub.elsevier.com/retrieve/pii/S1089860321000367|journal=Nitric Oxide|language=en|volume=111–112|pages=45–63|doi=10.1016/j.niox.2021.04.001|pmid=33838343|s2cid=233205099|url-access=subscription}}{{Cite book|last=Watt|first=J|url=https://books.google.com/books?id=Nk0-omJgDc4C&q=beddoes+hydrocarbonate&pg=PA244|title=The Monthly Magazine, "Original Letters of Mr. Watt to Dr. Lind; March 1795"|date=1820|publisher=R. Phillips|pages=244|language=en}} Georgiana Cavendish, Duchess of Devonshire (related to Henry through marriage) had a profound interest in chemistry with interest in Henry's research in pneumatic chemistry.{{cite journal | vauthors = Bergman NA | title = Georgiana, Duchess of Devonshire, and Princess Diana: a parallel | journal = Journal of the Royal Society of Medicine | volume = 91 | issue = 4 | pages = 217–9 | date = April 1998 | pmid = 9659313 | doi = 10.1177/014107689809100414 | pmc = 1296647 }} She played a pivotal role in advancing the study of factitious airs through partnering with Thomas Beddoes to establish the Pneumatic Institution.

Tuberculosis was a primary disease physicians had attempted to treat with factitious airs, particularly since James Watt's daughter died of the disease. John Carmichael had reported successfully treating a patient suffering from tuberculosis using hydrocarbonate.{{Cite book| vauthors = Dyck E, Stewart L |url=https://books.google.com/books?id=m669CwAAQBAJ&pg=PA164 |title=The Uses of Humans in Experiment: Perspectives from the 17th to the 20th Century|date=2016-03-24|publisher=BRILL|isbn=978-90-04-28671-9|language=en}} This application of factitious air was pioneering research relevant to the modern era as carbon monoxide currently has preclinical evidence of treating Mycobacterium tuberculosis infection progression by inducing dormancy, stimulating host immune response, and ameliorating host inflammation.{{cite journal | vauthors = Chinta KC, Saini V, Glasgow JN, Mazorodze JH, Rahman MA, Reddy D, Lancaster JR, Steyn AJ | display-authors = 6 | title = The emerging role of gasotransmitters in the pathogenesis of tuberculosis | journal = Nitric Oxide | volume = 59 | pages = 28–41 | date = September 2016 | pmid = 27387335 | pmc = 5028278 | doi = 10.1016/j.niox.2016.06.009 }}

{{reflist|30em}}

Category:17th-century neologisms

Category:Robert Boyle

Category:18th century in medicine

Category:History of pharmacy

Category:History of chemistry

Category:Misidentified chemical elements

Category:Gases