Faropenem
{{Short description|Chemical compound}}
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| routes_of_administration = Oral
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| CAS_number = 106560-14-9
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| PubChem = 65894
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| C=12 | H=15 | N=1 | O=5 | S=1
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Faropenem is an orally active beta-lactam antibiotic belonging to the penem group.{{cite journal |vauthors=Critchley IA, Brown SD, Traczewski MM, Tillotson GS, Janjic N |title=National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study |journal=Antimicrob. Agents Chemother. |volume=51 |issue=12 |pages=4382–9 |date=December 2007 |pmid=17908940 |pmc=2168020 |doi=10.1128/AAC.00971-07 |url=}} It is resistant to some forms of extended-spectrum beta-lactamase.{{cite journal |vauthors=Mushtaq S, Hope R, Warner M, Livermore DM |title=Activity of faropenem against cephalosporin-resistant Enterobacteriaceae |journal=J. Antimicrob. Chemother. |volume=59 |issue=5 |pages=1025–30 |date=May 2007 |pmid=17353220 |doi=10.1093/jac/dkm063 |doi-access=free }} It is available for oral use.{{cite journal |vauthors=Milazzo I, Blandino G, Caccamo F, Musumeci R, Nicoletti G, Speciale A |title=Faropenem, a new oral penem: antibacterial activity against selected anaerobic and fastidious periodontal isolates |journal=J. Antimicrob. Chemother. |volume=51 |issue=3 |pages=721–5 |date=March 2003 |pmid=12615878 |doi= 10.1093/jac/dkg120|doi-access=free }}
Forms
Faropenem was developed by Daiichi Asubio Pharma, which markets it in two forms.
- The sodium salt faropenem sodium, available under the trade name Farom, has been marketed in Japan since 1997. ({{PubChem|636379}})
- The sodium salt faropenem sodium, available under the trade name Orfanem, has been marketed in Bangladesh by Incepta Pharmaceuticals Ltd.
- The prodrug form faropenem medoxomil{{cite journal |vauthors=Gettig JP, Crank CW, Philbrick AH |title=Faropenem medoxomil |journal=Ann Pharmacother |volume=42 |issue=1 |pages=80–90 |date=January 2008 |pmid=18094341 |doi=10.1345/aph.1G232 |s2cid=28859560 |url=http://www.theannals.com/cgi/pmidlookup?view=long&pmid=18094341 |archive-url=https://archive.today/20130203200812/http://www.theannals.com/cgi/pmidlookup?view=long&pmid=18094341 |url-status=dead |archive-date=2013-02-03 |url-access=subscription }} (also known as faropenem daloxate) has been licensed from Daiichi Asubio Pharma by Replidyne, which plans to market it in conjunction with Forest Pharmaceuticals. The trade name proposed for the product was Orapem, but company officials recently announced this name was rejected by the FDA.(Q1 06 Investor Conf Call)({{PubChem|6918218}})
Clinical use
As of 8 September 2015, Faropenem has yet to receive marketing approval in the United States, and was submitted for consideration by the United States Food and Drug Administration (FDA) on 20 December 2005. The new drug application dossier submitted included these proposed indications:{{cn|date=March 2023}}
- acute bacterial sinusitis
- community-acquired pneumonia
- acute exacerbations of chronic bronchitis
- uncomplicated skin and skin structure infections
- urinary tract infections
History
The FDA refused to approve faropenem, an antibiotic manufactured by Louisville-based Replidyne. The FDA said the drug was “nonapprovable”, but did not refer to specific safety concerns about the product. The company will have to conduct new studies and clinical trials, lasting an estimated two more years, to prove the drug treats community-acquired pneumonia, bacterial sinusitis, chronic bronchitis, and skin infections.{{Citation needed|date=June 2015}}
In India it is available under the name Farokaa, and in Bangladesh as Orfanem.
References
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External links
- [https://www.drugbank.ca/drugs/DB12190/ DrugBank website]
{{CephalosporinAntiBiotics}}