Fayette National Bank Building

{{Use American English|date=February 2025}}

{{Use mdy dates|date=January 2025}}

{{Infobox NRHP

| name = Fayette National Bank Building

| nrhp_type =

| image = File:Fayette National Bank Building (1).jpg

| caption =

| location = 167 W. Main St., Lexington, Kentucky

| coordinates = {{coord|38|2|50|N|84|29|53|W|display=inline,title}}

| locmapin = Kentucky#USA

| built = 1913-1914

| builder = George A. Fuller Company

| architect = McKim, Mead & White

| architecture = Beaux Arts

| added = February 27, 1980

| area =

| refnum = 80001513{{NRISref|version=2010a}}

| nrhp_type2 = cp

| nocat = yes

| designated_nrhp_type2 = August 25, 1983

| partof = Downtown Commercial District

| partof_refnum = 83000559

}}

The Fayette National Bank Building, also known as the First National Bank Building or 21C Museum Hotel Lexington, is a historic 15-story high-rise in Lexington, Kentucky. The building was designed by the prominent architecture firm McKim, Mead & White and built by the George A. Fuller Company from 1913 to 1914. It was added to the National Register of Historic Places on February 27, 1980.{{cite web| url = {{NRHP url|id=80001513}}| title = National Register of Historic Places Nomination Form: Fayette National Bank Building| access-date = 2014-11-19|author1 =Walter Langsam|author2=Richard S. DeCamp| format = PDF| publisher=National Park Service|date= August 1979}} {{NRHP url|id=80001513|title=Photos|photos=y}}

In 2016 the building was converted into a 21c Museum Hotel. The building was reconfigured into 88 hotel rooms, a restaurant and museum space. Renovations were expected to cost in excess of $43 million.{{cite web|url=http://www.kentucky.com/2014/05/27/3262134/21c-museum-hotel-plans-to-begin.html|title=21c Museum Hotel plans to begin construction next month with completion in late 2015|publisher=Lexington Herald-Leader|author=Patton, Janet|date=2014-05-27|access-date=2014-06-03}} The hotel opened in December 2016. It was then inducted into [https://www.historichotels.org/us/ Historic Hotels of America], the official program of the National Trust for Historic Preservation, in 2019.{{Cite web |title=Hotel History - 21c Museum Hotel Lexington by MGallery |url=https://www.historichotels.org/us/hotels-resorts/21c-museum-hotel-lexington-by-mgallery/history.php |access-date=2022-12-14 |website=Historic Hotels of America |language=en}}