Fcab
{{short description|Antibodies fragments}}
{{about|the antibodies|the South American railway known as FCAB|Ferrocarril de Antofagasta a Bolivia}}
Fcabs are antibodies fragments engineered from the constant region of an antibody (Fc).{{cite journal |vauthors=Wozniak-Knopp G, Bartl S, Bauer A, Mostageer M, Woisetschläger M, Antes B, Ettl K, Kainer M, Weberhofer G, Wiederkum S, Himmler G, Mudde GC, Rüker F | title=Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties. | journal=Protein Eng Des | year=2010 | volume=23 | issue=4 | pages=289–297 | pmid=20150180 | doi=10.1093/protein/gzq005| doi-access=free }} In naturally occurring antibodies (such as IgGs), the antigen-binding sites are located at the variable regions (Fab).
Overview
Fcabs can be expressed as soluble proteins or they can be engineered back into a full IgG. This type of antibodies are therefore able to recognise two different antigens, one at their Fab region and a second one at the Fc region, hence the name of bispecific antibodies. This antibody fragment is part of the modular antibody technology of F-star Biotechnology Ltd.{{cn|date=February 2023}}
See also
References
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