Fenpentadiol

{{Short description|Chemical compound}}

{{Drugbox

| IUPAC_name = 2-(4-chlorophenyl)-4-methyl-pentane-2,4-diol

| image = Fenpentadiol.svg

| image_class = skin-invert-image

| tradename =

| pregnancy_category =

| legal_status = Rx-only

| routes_of_administration = Oral

| bioavailability =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number = 15687-18-0

| ATC_prefix = none

| ATC_suffix =

| PubChem = 85896

| ChEMBL = 2106273

| ChemSpiderID = 77482

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = BLO7300903

| C=12 | H=17 | Cl=1 | O=2

}}

Fenpentadiol (INN; brand names Tredum, Trefenum; developmental code Rd-292; also known as phenpentanediol) is a drug described as a tranquilizer and antidepressant that was formerly marketed in Europe.{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA258|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=258–}}{{cite book | author = O'Neil, Maryadele J. | title = The Merck index: an encyclopedia of chemicals, drugs, and biologicals | publisher = Merck Research Laboratories | location = Rahway, NJ | year = 2001 | isbn = 0-911910-13-1 | url = https://archive.org/details/merckindexency00onei | url-access = registration }} It also has stimulant, sedative, and anxiolytic effects, with the latter two occurring only at higher doses.{{cite journal |vauthors=Ginet J, Levy JC, Rolland D | title = [Psychotropic activity under the influence of fenpentadiol] | language = de | journal = Arzneimittel-Forschung | volume = 21 | issue = 1 | pages = 1–8 |date=January 1971 | pmid = 4396676 }}{{cite book | title=Annual Reports in Medicinal Chemistry Volume 7 | last = Heinzelman | first = Richard Voorhees | editor = Cornelius K. Cain | year = 1972 | publisher = Academic Press | isbn = 0-12-040507-5 | pages = 11 | url = https://books.google.com/books?id=52joNWUvZakC&pg=PA11}}

The following literature incidence of the fenpentadiol has been found and quoted:

{{Quote|text=In three articles the properties of a new psychotropic agent from the series of araliphatic alcohols — phenpentanediol (CXV) — were described (477-479). It is not easy to place this substance anywhere in the pharmacodynamic system of psychotropic agents: on the one hand it potentiates the barbiturate narcosis, on the other it increases motility and exploratory activity in mice and potentiates the effects of amphetamine.|author=|source={{cite book|title=Farmaco. Edizione Scientifica|url=https://books.google.com/books?id=VEy0AAAAIAAJ|year=1974|page=90}}}}