Fixed drug reaction
{{Infobox medical condition (new)
| name = Fixed drug reaction
| synonyms = Drug eruption
| image = Drug eruption2.jpg
| caption = Fixed drug eruption caused by phenolphthalein.
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Fixed drug reactions are common and so named because they recur at the same site with each exposure to a particular medication.{{cite book | vauthors = James W, Berger T, Elston D |year=2005 |title=Andrews' Diseases of the Skin: Clinical Dermatology |url=https://archive.org/details/andrewsdiseasess00mdwi_659 |url-access=limited |edition=10th |publisher=Saunders |isbn=978-0-7216-2921-6 |page=[https://archive.org/details/andrewsdiseasess00mdwi_659/page/n137 127]}} Medications inducing fixed drug eruptions are usually those taken intermittently.
Signs and symptoms
A painful and itchy reddish/purple patch of skin that occurs in the same location with repeated exposures to the causative drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.
Cause
Medications that are commonly implicated as a cause of fixed drug eruptions include the following:
- Cetirizine
- Ciprofloxacin
- Clarithromycin
- Cotrimoxazole
- Doxycycline
- Fluconazole
- NSAIDs (e.g., ibuprofen, etoricoxib, naproxen)
- Phenytoin
- Pseudoephedrine{{cite journal | vauthors = Vidal C, Prieto A, Pérez-Carral C, Armisén M | title = Nonpigmenting fixed drug eruption due to pseudoephedrine | journal = Annals of Allergy, Asthma & Immunology | volume = 80 | issue = 4 | pages = 309–310 | date = April 1998 | pmid = 9564979 | doi = 10.1016/S1081-1206(10)62974-2 }}
- Trimethoprim
See also
References
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External links
{{Medical resources
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| ICD10 = L27.1 (ILDS L27.110)
| ICD9 = {{ICD9|692.3}}
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{{Noninfectious inflammatory cutaneous conditions}}
{{Drug reactions|state=collapsed}}