Fleischer ring
{{Distinguish|Kayser–Fleischer ring}}
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|caption = Fleischer ring in keratoconus, by Mahmoud et al., 2022.{{cite journal | last1=Mahmoud | first1=Mohamed Magdy Ibrahim | last2=Hamdy | first2=Alaa Mohamed | last3=Mohamed | first3=Ashraf Bori | last4=Diaa El Din | first4=Yasmine Ahmed | title=An Updated Overview of Keratoconus Management: Review Article | journal=The Egyptian Journal of Hospital Medicine | publisher=Egypts Presidential Specialized Council for Education and Scientific Research | volume=88 | issue=1 | date=2022-07-01 | issn=2090-7125 | doi=10.21608/ejhm.2022.241951 | pages=2777–2780| s2cid=249531881 | doi-access=free }}
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|differential = keratoconus
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Fleischer rings are pigmented rings in the peripheral cornea, resulting from iron deposition{{cite web |url=http://dro.hs.columbia.edu/fleischer.htm |title=Cornea & External Diseases-Keratoconus Fleischer's Ring |access-date=2008-10-24 |archive-url=https://web.archive.org/web/20090210191314/http://dro.hs.columbia.edu/fleischer.htm |archive-date=2009-02-10 |url-status=dead }} in basal epithelial cells, in the form of hemosiderin.{{cite web |url=http://cancerweb.ncl.ac.uk/cgi-bin/omd?Fleischer%27s+ring |archive-url=https://archive.today/20070813174048/http://cancerweb.ncl.ac.uk/cgi-bin/omd?Fleischer's+ring |url-status=dead |archive-date=2007-08-13 |title=Definition: Fleischer's ring from Online Medical Dictionary |access-date=2008-10-24 }} They are usually yellowish to dark-brown, and may be complete or broken.{{Cite web|date=2021-01-12|title=Fleischer's Ring {{!}} Columbia Ophthalmology|url=https://www.columbiaeye.org/education/digital-reference-of-ophthalmology/cornea-external-diseases/degenerations/fleischers-ring|access-date=2021-01-12|archive-url=https://web.archive.org/web/20210112115950/https://www.columbiaeye.org/education/digital-reference-of-ophthalmology/cornea-external-diseases/degenerations/fleischers-ring|archive-date=2021-01-12}} The rings are best seen using the slit lamp under cobalt blue filter.
They are named for Bruno Fleischer.{{cite journal | author=Fleischer, B | title= Über Keratokonus und eigenartige Pigmentbildung in der Kornea| journal=Münchener medizinische Wochenschrift | year=1906 | volume=53 | pages= 625–626 }}
Fleischer rings are indicative of keratoconus,{{cite journal |vauthors=Hiratsuka Y, Nakayasu K, Kanai A |title=Secondary keratoconus with corneal epithelial iron ring similar to Fleischer's ring |journal=Japanese Journal of Ophthalmology |volume=44 |issue=4 |pages=381–6 |year=2000 |pmid=10974294 |doi= 10.1016/S0021-5155(00)00179-9}} a degenerative corneal condition that causes the cornea to thin and change to a conic shape.
Confusion with Kayser–Fleischer rings
Some confusion exists between Fleischer rings and Kayser–Fleischer rings. Kayser–Fleischer rings are caused by copper deposits in descemet's membrane of cornea, and are indicative of Wilson's disease, whereas Fleischer rings are caused by iron deposits in basal epithelial cells. One example of a medical condition that can present with Fleischer rings is keratoconus.