Focal nodular hyperplasia

File:Focal nodular hyperplasia liver 0521105219312.jpg

File:Liver tumor types in adults by relative incidence.png

Focal nodular hyperplasia's most recognizable gross feature is a central stellate scar seen in 60–70% of cases. Microscopically, a lobular proliferation of bland-appearing hepatocytes with a bile ductular proliferation and malformed vessels within the fibrous scar is the most common pattern. Other patterns include telangiectatic, hyperplastic-adenomatous, and lesions with focal large-cell dysplasia.{{cite journal |last1=Nguyen |first1=Bich N. |last2=Fléjou |first2=Jean-François |last3=Terris |first3=Benoit |last4=Belghiti |first4=Jacques |last5=Degott |first5=Claude |title=Focal Nodular Hyperplasia of the Liver |journal=The American Journal of Surgical Pathology |volume=23 |issue=12 |pages=1441–54 |year=1999 |pmid=10584697 |doi=10.1097/00000478-199912000-00001 }} Rarely, these lesions may be multiple or can occur as part of a syndrome with hemangiomas, epithelioid hemangioendothelioma, hepatic adenomas, fibrolamellar hepatocellular carcinoma, vascular malformations of the brain, meningiomas, and/or astrocytomas.

Focal nodular hyperplasia is not a neoplasm; it is believed to result from localized hyperplastic hepatocyte response to an underlying congenital arteriovenous malformation.{{Citation |last1=Hamad |first1=Sammy |title=Focal Nodular Hyperplasia |date=2023 |url=http://www.ncbi.nlm.nih.gov/books/NBK532244/ |work=StatPearls |access-date=2023-11-03 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=30335277 |last2=Willyard |first2=Charles E. |last3=Mukherjee |first3=Sandeep}} It consists of normal liver constituents in an abnormally organized pattern, grows in a stellate pattern and may display central necrosis when large.{{EMedicine|article|368377|Imaging in Focal Nodular Hyperplasia}} Additionally evidence suggests that the incidence of focal nodular hyperplasia is related to oral contraceptive use.{{cite journal |last1=Scalori |first1=Astrid |last2=Tavani |first2=Alessandra |last3=Gallus |first3=Silvano |last4=La Vecchia |first4=Carlo |last5=Colombo |first5=Massimo |title=Oral contraceptives and the risk of focal nodular hyperplasia of the liver: A case-control study |journal=American Journal of Obstetrics and Gynecology |volume=186 |issue=2 |pages=195–7 |year=2002 |pmid=11854634 |doi=10.1067/mob.2002.120277 }}

Unenhanced CT or MRI usually does not show the difference in intensity between the focal nodular hyperplasia and surrounding liver except when there is marked liver steatosis that reduces the attenuation of the liver, causing focal nodular hyperplasia to be hyperattenuating when compared with the surrounding liver. In the arterial phase CT or MRI, there is a strong enhancement not followed by washout. The lesion presents a slight hyperintensity or isodensity on portal venous phase or delayed phase images. There is also a presence of a central scar and absence of a capsule for the focal nodular hyperplasia.{{Cite journal |last1=Dioguardi Burgio |first1=Marco |last2=Ronot |first2=Maxime |last3=Salvaggio |first3=Giuseppe |last4=Vilgrain |first4=Valérie |last5=Brancatelli |first5=Giuseppe |date=December 2016 |title=Imaging of Hepatic Focal Nodular Hyperplasia: Pictorial Review and Diagnostic Strategy |url=https://linkinghub.elsevier.com/retrieve/pii/S0887217116300634 |journal=Seminars in Ultrasound, CT and MRI |language=en |volume=37 |issue=6 |pages=511–524 |doi=10.1053/j.sult.2016.08.001|pmid=27986170 |url-access=subscription }}

Frequent monitoring through periodic imaging at intervals of three to six months is advised. Nevertheless, in cases where a patient exhibits symptoms, when there are suspicions of an underlying malignancy following an inconclusive biopsy, or when a lesion demonstrates sustained growth, medical professionals commonly opt for a biopsy or surgical removal. Surgical resection remains the established and definitive course of treatment.{{Cite journal |last1=Fodor |first1=Margot |last2=Primavesi |first2=Florian |last3=Braunwarth |first3=Eva |last4=Cardini |first4=Benno |last5=Resch |first5=Thomas |last6=Bale |first6=Reto |last7=Putzer |first7=Daniel |last8=Henninger |first8=Benjamin |last9=Oberhuber |first9=Rupert |last10=Maglione |first10=Manuel |last11=Margreiter |first11=Christian |last12=Schneeberger |first12=Stefan |last13=Öfner |first13=Dietmar |last14=Stättner |first14=Stefan |date=2018 |title=Indications for liver surgery in benign tumours |journal=European Surgery |volume=50 |issue=3 |pages=125–131 |doi=10.1007/s10353-018-0536-y |issn=1682-8631 |pmc=5968066 |pmid=29875801}}

The prevalence of focal nodular hyperplasia in individuals undergoing evaluation with an ultrasound of the abdomen is 0.03%.{{cite journal |last1=Myers |first1=L |last2=Ahn |first2=J |title=Focal Nodular Hyperplasia and Hepatic Adenoma: Evaluation and Management. |journal=Clinics in Liver Disease |date=August 2020 |volume=24 |issue=3 |pages=389–403 |doi=10.1016/j.cld.2020.04.013 |pmid=32620279|s2cid=220335859 }} About 20% of focal nodular hyperplasia lesions are associated with hepatic hemangiomas.

{{Reflist}}

{{refbegin}}

• {{cite journal |last1=Chun Hsee |first1=Li |last2=McCall |first2=John L. |last3=Koea |first3=Jonathan B. |title=Focal nodular hyperplasia: what are the indications for resection? |journal=HPB |volume=7 |issue=4 |pages=298–302 |year=2005 |pmid=18333211 |pmc=2043107 |doi=10.1080/13651820500273624 }}

{{refend}}

{{Medical resources

| DiseasesDB = 33467

| ICD10 = {{ICD10|K76.8}}

| ICD9 =

| ICDO =

| OMIM =

| MedlinePlus =

| eMedicineSubj = radio

| eMedicineTopic = 286

| MeshID = D020518

}}

{{Digestive system neoplasia}}

Category:Hepatology