Formate dehydrogenase (NADP+)

{{infobox enzyme

| Name = formate dehydrogenase (NADP+)

| EC_number = 1.17.1.10

| CAS_number = 51377-43-6

| GO_code = 0047899

| image =

| width =

| caption =

}}

In enzymology, a formate dehydrogenase (NADP+) ({{EC number|1.17.1.10}}) is an enzyme that catalyzes the chemical reaction

:formate + NADP⁺ $\rightleftharpoons$ CO₂ + NADPH

Thus, the two substrates of this enzyme are formate and NADP⁺, whereas its two products are CO₂ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formate:NADP+ oxidoreductase. Other names in common use include NADP+-dependent formate dehydrogenase, and formate dehydrogenase (NADP+). This enzyme participates in methane metabolism. It has 3 cofactors: iron, Tungsten, and Selenium.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|2GSD}}.

References

{{cite journal | vauthors = Andreesen JR, Ljungdahl LG | date = 1974 | title = Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties | journal = J. Bacteriol. | volume = 120 | pages = 6–14 | pmid = 4154039 | issue = 1 | doi = 10.1128/JB.120.1.6-14.1974 | pmc = 245723 }}
{{cite journal | vauthors = Yamamoto I, Saiki T, Liu SM, Ljungdahl LG | date = 1983 | title = Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein | journal = J. Biol. Chem. | volume = 258 | pages = 1826–32 | pmid = 6822536 | issue = 3 | doi = 10.1016/S0021-9258(18)33062-X | doi-access = free }}

Category:EC 1.17.1

Category:NADPH-dependent enzymes

Category:Iron enzymes

Category:Tungsten enzymes

Category:Enzymes of known structure