Francis I

• Francis I of France (1494–1547), King of France, reigned 1515–1547
• Francis I, Holy Roman Emperor (1708–1765), reigned 1745–1765
• Francis II, Holy Roman Emperor, also known as Francis I, Emperor of Austria, (1768–1835), reigned 1804–1835
• Francis I of the Two Sicilies (1777–1830), reigned 1825–1830

• Francis I, Duke of Brittany (1414–1450), reigned 1442–1450
• Francis I, Duke of Saxe-Lauenburg (1510–1581), reigned 1543–1571
• Francis I, Duke of Nevers (1516–1561), reigned 1539–1561
• Francis I, Duke of Lorraine (1517–1545), reigned 1544–1545
• Francesco I de' Medici, Grand Duke of Tuscany (1541–1587), reigned 1574–1587
• Francesco I d'Este, Duke of Modena (1610–1658), reigned 1644–1658

• Francesco I Gonzaga (1366–1407)
• Francis I of Beauharnais (died 1587), leading noble of the French House of Beauharnais
• Francis I Rákóczi (1645–1676), elected prince of Transylvania
• Francis I (Erbach-Erbach) (1754–1823), Count of Erbach
• Franz I, Prince of Liechtenstein (1853–1938)
• Pope Francis (1936–2025), leader of the Catholic Church from 2013 to 2025

• Francis the First (play), an 1832 play by Fanny Kemble
• Francis the First (film), a 1937 French historical comedy film
• Francis the First, an opera composed by Edward Loder

• Francesco I (disambiguation)
• Francisco I. Madero (1873–1913), Mexican revolutionary, writer and statesman; 37th president of Mexico
• Franz Joseph I, Prince of Liechtenstein
• Franz Joseph I of Austria

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