Francisco Téllez-Girón, 10th Duke of Osuna

{{Short description|Spanish nobleman}}

{{no footnotes|date=August 2018}}

{{Infobox noble|

| name =Francisco Téllez-Girón, 10th Duke of Osuna

| image =10th Duke of Osuna by Goya.jpg

| caption =Don Francisco de Borja Tellez Giron, by Francisco de Goya, Musée Bonnat

| spouse =Marie-Françoise-Philippine Beaufort-Spontin

| issue =Pedro de Alcántara Téllez-Girón y Beaufort Spontin, 14th Duke of the Infantado

| noble family =House of Osuna

| father =Pedro Téllez-Girón, 9th Duke of Osuna

| mother =María Josefa Pimentel, Duchess of Osuna

| brother =

| birth_date ={{birth date|1785|10|6|df=y}}

| birth_place =

| death_date ={{death date and age|1820|5|21|1785|10|6|df=y}}

| death_place =

| signature =

}}

Francisco de Borja Téllez-Girón y Pimentel, 10th Duke de Osuna (6 October 1785 – 21 May 1820), Grandee of Spain, was a Spanish nobleman.

Francisco Téllez-Girón was the 7th son of Pedro Téllez-Girón, 9th Duke of Osuna (1756–1807). In 1802, he married Countess Marie Françoise Philippine Beaufort-Spontin (1785–1830), daughter of Frederic Augustus Alexander, Duke of Beaufort-Spontin and his wife Leopoldina Álvarez de Toledo (1760–1792), who in turn was the daughter of Pedro de Alcántara Álvarez de Toledo y Silva, 12th Duke of the Infantado.

Their son, the 11th Duke, Pedro de Álcantara was born in 1810, but died in 1844 without issue.