Frizzled-1

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.

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• {{cite journal | vauthors = Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 17 | pages = 10164–9 | date = Aug 1998 | pmid = 9707618 | pmc = 21479 | doi = 10.1073/pnas.95.17.10164 | bibcode = 1998PNAS...9510164T | doi-access = free }}
• {{cite journal | vauthors = Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA | title = Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response | journal = Oncogene | volume = 18 | issue = 44 | pages = 5959–66 | date = Oct 1999 | pmid = 10557084 | doi = 10.1038/sj.onc.1202985 | doi-access = free }}
• {{cite journal | vauthors = DeCostanzo AJ, Huang XP, Wang HY, Malbon CC | title = The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor | journal = Naunyn-Schmiedeberg's Archives of Pharmacology | volume = 365 | issue = 5 | pages = 341–8 | date = May 2002 | pmid = 12012019 | doi = 10.1007/s00210-002-0540-3 | s2cid = 8192909 }}
• {{cite journal | vauthors = Hering H, Sheng M | title = Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 | journal = FEBS Letters | volume = 521 | issue = 1–3 | pages = 185–9 | date = Jun 2002 | pmid = 12067714 | doi = 10.1016/S0014-5793(02)02831-4 | s2cid = 39243103 | doi-access = free }}
• {{cite journal | vauthors = Zilberberg A, Yaniv A, Gazit A | title = The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway | journal = The Journal of Biological Chemistry | volume = 279 | issue = 17 | pages = 17535–42 | date = Apr 2004 | pmid = 14739301 | doi = 10.1074/jbc.M311292200 | doi-access = free }}
• {{cite journal | vauthors = Wu J, Klein TJ, Mlodzik M | title = Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity | journal = PLOS Biology | volume = 2 | issue = 7 | pages = E158 | date = Jul 2004 | pmid = 15252441 | pmc = 449784 | doi = 10.1371/journal.pbio.0020158 | doi-access = free }} {{open access}}
• {{cite journal | vauthors = Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y | title = Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) | journal = Ophthalmic Genetics | volume = 25 | issue = 2 | pages = 81–90 | date = Jun 2004 | pmid = 15370539 | doi = 10.1080/13816810490514270 | s2cid = 32817238 }}
• {{cite journal | vauthors = Yang L, Yamasaki K, Shirakata Y, Dai X, Tokumaru S, Yahata Y, Tohyama M, Hanakawa Y, Sayama K, Hashimoto K | title = Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes | journal = Journal of Dermatological Science | volume = 42 | issue = 2 | pages = 111–9 | date = May 2006 | pmid = 16442268 | doi = 10.1016/j.jdermsci.2005.12.011 }}

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• {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3059 | title = Frizzled Receptors: FZD₁ | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-04 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303203744/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3059 | url-status = dead }}

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{{G protein-coupled receptors|g4}}

Category:G protein-coupled receptors

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