Ftx (gene)

{{Short description|Genetic element in the species Homo sapiens}}

{{Infobox_gene}}

In molecular biology, FTX transcript, XIST regulator (non-protein coding), also known as FTX (Five prime to Xist), is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the XIST gene.{{cite journal|vauthors=Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L | title=Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine. | journal=Genome Res | year= 2002 | volume= 12 | issue= 6 | pages= 894–908 | pmid=12045143 | doi=10.1101/gr.152902 | pmc=1383731 |display-authors=etal}} FTX contains several microRNAs within its introns.{{cite journal|vauthors=Chureau C, Chantalat S, Romito A, Galvani A, Duret L, Avner P | title=Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. | journal=Hum Mol Genet | year= 2011 | volume= 20 | issue= 4 | pages= 705–718 | pmid=21118898 | doi=10.1093/hmg/ddq516 |display-authors=etal| doi-access=free }} It upregulates expression of XIST, and inhibits DNA methylation of the XIST promoter.