Functional analog (chemistry)

In chemistry and pharmacology, functional analogs are chemical compounds that have similar physical, chemical, biochemical, or pharmacological properties. Functional analogs are not necessarily structural analogs with a similar chemical structure.{{cite journal|doi=10.1021/jm020155c|pmid=12213076|title=Do Structurally Similar Molecules Have Similar Biological Activity?|journal=Journal of Medicinal Chemistry|volume=45|issue=19|pages=4350–8|year=2002|last1=Martin|first1=Yvonne C.|last2=Kofron|first2=James L.|last3=Traphagen|first3=Linda M.}} An example of pharmacological functional analogs are morphine, heroin and fentanyl, which have the same mechanism of action, but fentanyl is structurally quite different from the other two with significant variance in dosage.{{Cite book|last1=Mutschler|first1=Ernst|last2=Schäfer-Korting|first2=Monika|title=Arzneimittelwirkungen|language=German|location=Stuttgart|publisher=Wissenschaftliche Verlagsgesellschaft|year=2001|edition=8|pages=214f, 286|isbn=3-8047-1763-2}}

File:Morphin - Morphine.svg|Morphine

File:Heroin - Heroine.svg|Heroin

File:Fentanyl2DCSD.svg|Fentanyl