Fusion transcript

Fusion transcript is a chimeric RNA encoded by a fusion gene{{cite journal |pmid=17361217 |year=2007 |author1=Mitelman |first2=B |first3=F |title=The impact of translocations and gene fusions on cancer causation |volume=7 |issue=4 |pages=233–45 |doi=10.1038/nrc2091 |journal=Nature Reviews. Cancer |last2=Johansson |last3=Mertens|s2cid=26093482 }} or by two different genes by subsequent trans-splicing.{{cite journal |pmid=18772439 |year=2008 |author1=Li |first2=J |first3=G |first4=J |title=A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells |volume=321 |issue=5894 |pages=1357–61 |doi=10.1126/science.1156725 |journal=Science |last2=Wang |last3=Mor |last4=Sklar|bibcode=2008Sci...321.1357L |s2cid=13605087 }}{{cite journal |pmid=19293179 |year=2009 |last1=Rickman |first2=D |first3=B |first4=VE |first5=CX |first6=A |first7=R |first8=AK |first9=SR |last10=Demichelis |first10=F. |last11=Rubin |first11=M. A. |title=SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer |volume=69 |issue=7 |pages=2734–8 |doi=10.1158/0008-5472.CAN-08-4926 |journal=Cancer Research |first1=F |last2=Pflueger |last3=Moss |last4=Vandoren |last5=Chen |last6=De La Taille |last7=Kuefer |last8=Tewari |last9=Setlur|display-authors=8 |pmc=4063441 }} Certain fusion transcripts are commonly produced by cancer cells, and detection of fusion transcripts is part of routine diagnostics of certain cancer types.