GABRA6
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.{{cite journal |vauthors=Hicks AA, Bailey ME, Riley BP, Kamphuis W, Siciliano MJ, Johnson KJ, Darlison MG | title = Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis | journal = Genomics | volume = 20 | issue = 2 | pages = 285–288 |date=Aug 1994 | pmid = 8020978 | doi = 10.1006/geno.1994.1167 | url = http://dare.uva.nl/personal/pure/en/publications/further-evidence-for-clustering-of-human-gabaa-receptor-subunit-genes-localization-of-the-alpha6subunit-gene-gabra6-to-distal-chromosome-5q-by-linkage-analysis(75bbc562-d88d-441d-a566-dc3e76a66f70).html }}{{cite web | title = Entrez Gene: GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2559}}
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
One study found a genetic variant in the gene to be associated with the personality trait neuroticism.{{Cite journal
| author = Srijan Sen
| author-link = Srijan Sen
| author2 = Sandra Villafuerte
| author2-link = Sandra Villafuerte
| author3 = Randolph Nesse
| author3-link = Randolph Nesse
| author4 = Scott F. Stoltenberg
| author4-link = Scott F. Stoltenberg
| author5 = Jeffrey Hopcian
| author5-link = Jeffrey Hopcian
| author6 = Lillian Gleiberman
| author6-link = Lillian Gleiberman
| author7 = Alan Weder
| author7-link = Alan Weder
| author8 = Margit Burmeister
| author8-link = Margit Burmeister
| name-list-style = amp
| title = Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism
| journal = Biological Psychiatry
| volume = 55
| issue = 3
| pages = 244–249
|date=February 2004
| pmid = 14744464
| doi = 10.1016/j.biopsych.2003.08.006
| s2cid = 7244510
| url = https://digitalcommons.unl.edu/psychfacpub/448
| url-access = subscription
}}
See also
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Tögel M, Mossier B, Fuchs K, Sieghart W |title=gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12993–12998 |year= 1994 |doi=10.1016/S0021-9258(18)99974-6 |pmid= 8175718 |doi-access=free }}
- {{cite journal |vauthors=Hadingham KL, Garrett EM, Wafford KA |title=Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. |journal=Mol. Pharmacol. |volume=49 |issue= 2 |pages= 253–259 |year= 1996 |doi=10.1016/S0026-895X(25)08706-1 |pmid= 8632757 |display-authors=etal}}
- {{cite journal | author=Russek SJ |title=Evolution of GABA(A) receptor diversity in the human genome. |journal=Gene |volume=227 |issue= 2 |pages= 213–222 |year= 1999 |pmid= 10023064 |doi=10.1016/S0378-1119(98)00594-0 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Sen S, Villafuerte S, Nesse R |title=Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. |journal=Biol. Psychiatry |volume=55 |issue= 3 |pages= 244–249 |year= 2004 |pmid= 14744464 |doi=10.1016/j.biopsych.2003.08.006 |s2cid=7244510 |display-authors=etal|url=https://digitalcommons.unl.edu/psychfacpub/448 |url-access=subscription }}
- {{cite journal |vauthors=Peran M, Hooper H, Rayner SL |title=GABAA receptor alpha1 and alpha6 subunits mediate cell surface anchoring in cultured cells. |journal=Neurosci. Lett. |volume=364 |issue= 2 |pages= 67–70 |year= 2004 |pmid= 15196679 |doi= 10.1016/j.neulet.2004.03.081 |s2cid=54314537 |display-authors=etal}}
- {{cite journal |vauthors=Uhart M, McCaul ME, Oswald LM |title=GABRA6 gene polymorphism and an attenuated stress response. |journal=Mol. Psychiatry |volume=9 |issue= 11 |pages= 998–1006 |year= 2005 |pmid= 15197399 |doi= 10.1038/sj.mp.4001535 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Wang W, Stock RE, Gronostajski RM |title=A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53491–53497 |year= 2005 |pmid= 15466411 |doi= 10.1074/jbc.M410370200 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
- {{cite journal |vauthors=Lucht M, Barnow S, Schroeder W |title=Negative perceived paternal parenting is associated with dopamine D2 receptor exon 8 and GABA(A) alpha 6 receptor variants: an explorative study. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 2 |pages= 167–172 |year= 2006 |pmid= 16402352 |doi= 10.1002/ajmg.b.30255 |s2cid=9675791 |display-authors=etal}}
- {{cite journal |vauthors=Park CS, Park SY, Lee CS |title=Association between alcoholism and the genetic polymorphisms of the GABAA receptor genes on chromosome 5q33-34 in Korean population. |journal=J. Korean Med. Sci. |volume=21 |issue= 3 |pages= 533–538 |year= 2007 |pmid= 16778401 |doi=10.3346/jkms.2006.21.3.533 | pmc=2729963 |display-authors=etal}}
- {{cite journal |vauthors=Kobayashi Y, Akiyoshi J, Kanehisa M |title=Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder. |journal=Psychiatr. Genet. |volume=17 |issue= 1 |pages= 9 |year= 2007 |pmid= 17167337 |doi= 10.1097/YPG.0b013e32801118bc |display-authors=etal}}
- {{cite journal |vauthors=Lee YC, Wang HP, Chiu HM |title=GABRA6 genetic polymorphism is associated with the risk of functional heartburn in Chinese. |journal=J. Gastroenterol. Hepatol. |volume=22 |issue= 2 |pages= 227–233 |year= 2007 |pmid= 17295876 |doi= 10.1111/j.1440-1746.2006.04441.x |s2cid=24860500 |display-authors=etal}}
{{refend}}
External links
- {{MeshName|GABRA6+protein,+human}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{GABAergics}}
{{membrane-protein-stub}}