GABRE
{{Short description|Protein-coding gene in humans}}
{{cs1 config|name-list-style=vanc}}{{Infobox_gene}}
Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene.{{cite journal |vauthors=Davies PA, Hanna MC, Hales TG, Kirkness EF | title = Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit | journal = Nature | volume = 385 | issue = 6619 | pages = 820–823 |date=Mar 1997 | pmid = 9039914 | doi = 10.1038/385820a0 | bibcode = 1997Natur.385..820D | s2cid = 4241881 }}{{cite journal |vauthors=Garret M, Bascles L, Boue-Grabot E, Sartor P, Charron G, Bloch B, Margolskee RF | title = An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system | journal = J Neurochem | volume = 68 | issue = 4 | pages = 1382–1389 |date=Apr 1997 | pmid = 9084408 | doi =10.1046/j.1471-4159.1997.68041382.x | url = https://hal.archives-ouvertes.fr/hal-02862782/file/J%20Neurochem%201997%20Garret.pdf | doi-access = free }}{{cite web | title = Entrez Gene: GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2564}}
The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.
Brainstem expression of ε subunit-containing GABAA receptors is upregulated during pregnancy, particularly in the ventral respiratory group.{{cite journal | pmid = 22303446 | doi=10.1371/journal.pone.0030608 | volume=7 | title=Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy | pmc=3269439 | year=2012 | journal=PLOS ONE | page=e30608 | vauthors=Hengen KB, Nelson NR, Stang KM, Johnson SM, Crader SM, Watters JJ, Mitchell GS, Behan M| issue=1 | doi-access=free | bibcode=2012PLoSO...730608H }}
See also
References
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Further reading
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- {{cite journal |vauthors=Jones BL, Henderson LP |title=Trafficking and potential assembly patterns of epsilon-containing GABAA receptors |journal=J. Neurochem. |volume=103 |issue= 3 |pages= 1258–1271 |year= 2007 |pmid= 17714454 |doi= 10.1111/j.1471-4159.2007.04833.x |doi-access= |s2cid=85020515 }}
- {{cite journal |vauthors=Rosen A, Bali M, Horenstein J, Akabas MH |title=Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment |journal=Biophys. J. |volume=92 |issue= 9 |pages= 3130–3139 |year= 2007 |pmid= 17293408 |doi= 10.1529/biophysj.106.094490 | pmc=1852347 |bibcode=2007BpJ....92.3130R }}
- {{cite journal |vauthors=Wilkins ME, Hosie AM, Smart TG |title=Proton modulation of recombinant GABA(A) receptors: influence of GABA concentration and the beta subunit TM2-TM3 domain |journal=J. Physiol. |volume=567 |issue= Pt 2 |pages= 365–377 |year= 2005 |pmid= 15946973 |doi= 10.1113/jphysiol.2005.088823 | pmc=1474194 }}
- {{cite journal |vauthors=Porter BE, Zhang G, Celix J |title=Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients |journal=Neurobiol. Dis. |volume=18 |issue= 3 |pages= 484–491 |year= 2005 |pmid= 15755675 |doi= 10.1016/j.nbd.2004.12.010 |s2cid=10973066 |display-authors=etal}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Davies PA, McCartney MR, Wang W |title=Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat |journal=Neuropharmacology |volume=43 |issue= 4 |pages= 467–475 |year= 2002 |pmid= 12367593 |doi=10.1016/S0028-3908(02)00153-3 |s2cid=54340902 |display-authors=etal}}
- {{cite journal |vauthors=Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER |title=GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus |journal=J. Neurosci. |volume=20 |issue= 10 |pages= 3588–3595 |year= 2000 |pmid= 10804200 |doi= 10.1523/jneurosci.20-10-03588.2000|pmc=6772669 |doi-access=free }}
- {{cite journal | author=Russek SJ |title=Evolution of GABA(A) receptor diversity in the human genome |journal=Gene |volume=227 |issue= 2 |pages= 213–222 |year= 1999 |pmid= 10023064 |doi=10.1016/S0378-1119(98)00594-0 }}
- {{cite journal |vauthors=Wilke K, Gaul R, Klauck SM, Poustka A |title=A gene in human chromosome band Xq28 (GABRE) defines a putative new subunit class of the GABAA neurotransmitter receptor |journal=Genomics |volume=45 |issue= 1 |pages= 1–10 |year= 1997 |pmid= 9339354 |doi= 10.1006/geno.1997.4885 }}
- {{cite journal |vauthors=Whiting PJ, McAllister G, Vassilatis D |title=Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published] |journal=J. Neurosci. |volume=17 |issue= 13 |pages= 5027–5037 |year= 1997 |pmid= 9185540 |doi= 10.1523/jneurosci.17-13-05027.1997|pmc=6573323 |display-authors=etal|doi-access=free }}
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External links
- {{MeshName|GABRE+protein,+human}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{membrane-protein-stub}}