GABRG3
Function
GABRG3 is a subunit of the GABAA receptor for the neurotransmitter gamma-Aminobutyric acid (GABA).{{cite web | title = Entrez Gene: GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2567}}
Association with alcoholism
Genetic markers near the GABRG3 gene are statistically linked to alcoholism.{{cite journal |vauthors=Dick DM, Edenberg HJ, Xuei X, Goate A, Kuperman S, Schuckit M, Crowe R, Smith TL, Porjesz B, Begleiter H, Foroud T | title = Association of GABRG3 with alcohol dependence | journal = Alcohol. Clin. Exp. Res. | volume = 28 | issue = 1 | pages = 4–9 |date=January 2004 | pmid = 14745296 | doi = 10.1097/01.ALC.0000108645.54345.98 | citeseerx = 10.1.1.418.2528 }}
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Greger V, Knoll JH, Woolf E |title=The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. |journal=Genomics |volume=26 |issue= 2 |pages= 258–264 |year= 1995 |pmid= 7601451 |doi=10.1016/0888-7543(95)80209-5 |display-authors=etal}}
- {{cite journal |vauthors=Tögel M, Mossier B, Fuchs K, Sieghart W |title=gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12993–12998 |year= 1994 |doi=10.1016/S0021-9258(18)99974-6 |pmid= 8175718 |doi-access=free }}
- {{cite journal |vauthors=Hadingham KL, Wafford KA, Thompson SA |title=Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. |journal=Eur. J. Pharmacol. |volume=291 |issue= 3 |pages= 301–309 |year= 1996 |pmid= 8719414 |doi= 10.1016/0922-4106(95)90070-5|display-authors=etal}}
- {{cite journal |vauthors=Poulsen CF, Christjansen KN, Hastrup S, Hartvig L |title=Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor. |journal=Brain Res. Mol. Brain Res. |volume=78 |issue= 1–2 |pages= 201–203 |year= 2000 |pmid= 10891602 |doi=10.1016/S0169-328X(00)00085-1 }}
- {{cite journal |vauthors=Harrington JJ, Sherf B, Rundlett S |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–445 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 |s2cid=25064683 |display-authors=etal}}
- {{cite journal |vauthors=Nymann-Andersen J, Wang H, Chen L |title=Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors. |journal=J. Neurochem. |volume=80 |issue= 5 |pages= 815–823 |year= 2002 |pmid= 11948245 |doi=10.1046/j.0022-3042.2002.00762.x |s2cid=38049055 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Dick DM, Edenberg HJ, Xuei X |title=Association of GABRG3 with alcohol dependence. |journal=Alcohol. Clin. Exp. Res. |volume=28 |issue= 1 |pages= 4–9 |year= 2004 |pmid= 14745296 |doi= 10.1097/01.ALC.0000108645.54345.98 |display-authors=etal|citeseerx=10.1.1.418.2528 }}
- {{cite journal |vauthors=Gole L, Crolla JA, Thomas SN |title=Characterization of breakpoints in the GABRG3 and TSPY genes in a family with a t(Y;15)(p11.2;q12). |journal=Am. J. Med. Genet. A |volume=125 |issue= 2 |pages= 177–180 |year= 2004 |pmid= 14981720 |doi= 10.1002/ajmg.a.20482 |s2cid=44727697 |display-authors=etal}}
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External links
- {{MeshName|GABRG3+protein,+human}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{membrane-protein-stub}}