GABRP
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.{{cite journal |vauthors=Hedblom E, Kirkness EF | title = A novel class of GABAA receptor subunit in tissues of the reproductive system | journal = J Biol Chem | volume = 272 | issue = 24 | pages = 15346–15350 |date=Jul 1997 | pmid = 9182563 | doi =10.1074/jbc.272.24.15346 | doi-access = free }}{{cite web | title = Entrez Gene: GABRP gamma-aminobutyric acid (GABA) A receptor, pi| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2568}}
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
See also
References
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Further reading
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- {{cite journal |vauthors=Mehta AK, Ticku MK |title=An update on GABAA receptors. |journal=Brain Res. Brain Res. Rev. |volume=29 |issue= 2–3 |pages= 196–217 |year= 1999 |pmid= 10209232 |doi=10.1016/S0165-0173(98)00052-6 |s2cid=34393842 }}
- {{cite journal |vauthors=Zafrakas M, Chorovicer M, Klaman I |title=Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue |journal=Int. J. Cancer |volume=118 |issue= 6 |pages= 1453–1459 |year= 2007 |pmid= 16187283 |doi= 10.1002/ijc.21517 |s2cid=21983109 |display-authors=etal}}
- {{cite journal |vauthors=Petryshen TL, Middleton FA, Tahl AR |title=Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia |journal=Mol. Psychiatry |volume=10 |issue= 12 |pages= 1074–1088, 1057 |year= 2006 |pmid= 16172613 |doi= 10.1038/sj.mp.4001739 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Galey D, Becker K, Haughey N |title=Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 358–371 |year= 2003 |pmid= 12775419 |doi=10.1080/13550280390201119 |s2cid=22016092 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal |bibcode=2002PNAS...9916899M|doi-access=free }}
- {{cite journal |vauthors=Neelands TR, Macdonald RL |title=Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors |journal=Mol. Pharmacol. |volume=56 |issue= 3 |pages= 598–610 |year= 1999 |pmid= 10462548 |doi= 10.1124/mol.56.3.598}}
- {{cite journal |vauthors=Taylor PM, Thomas P, Gorrie GH |title=Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression |journal=J. Neurosci. |volume=19 |issue= 15 |pages= 6360–6371 |year= 1999 |pmid= 10414965 |doi= 10.1523/jneurosci.19-15-06360.1999|display-authors=etal |pmc=6782825}}
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External links
- {{MeshName|GABRP+protein,+human}}
{{NLM content}}
{{Ligand-gated ion channels}}