GAD2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Glutamate decarboxylase 2 is an enzyme that in humans is encoded by the GAD2 gene.{{cite journal | vauthors = Cram DS, Barnett LD, Joseph JL, Harrison LC | title = Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets | journal = Biochem. Biophys. Res. Commun. | volume = 176 | issue = 3 | pages = 1239–44 | date = July 1991 | pmid = 2039509 | doi = 10.1016/0006-291X(91)90418-7 }}

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff-person syndrome.{{cite web | title = Entrez Gene: GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2572}}