GALNT2
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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Polypeptide N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the GALNT2 gene.{{cite journal |vauthors=Bennett EP, Weghuis DO, Merkx G, van Kessel AG, Eiberg H, Clausen H | title = Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family | journal = Glycobiology | volume = 8 | issue = 6 | pages = 547–55 |date=Jul 1998 | pmid = 9592121 | doi =10.1093/glycob/8.6.547 | doi-access = free }}{{cite journal |vauthors=White T, Bennett EP, Takio K, Sorensen T, Bonding N, Clausen H | title = Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase | journal = J Biol Chem | volume = 270 | issue = 41 | pages = 24156–65 |date=Dec 1995 | pmid = 7592619 | doi =10.1074/jbc.270.41.24156 | doi-access = free }}
This gene encodes polypeptide N-acetylgalactosaminyltransferase 2, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. The localization site of this particular enzyme is preponderantly the trans-Golgi.{{cite journal | title = African Swine Fever Virus Causes Microtubule-Dependent Dispersal of trans-Golgi Network| journal = Journal of Virology| date = November 2006| volume = 80| issue = 22| pages = 11385–11392| doi = 10.1128/JVI.00439-06| url = http://jvi.asm.org/cgi/reprint/80/22/11385.pdf| last1 = Netherton| first1 = Christopher L.| last2 = McCrossan| first2 = Mari-Clare| last3 = Denyer| first3 = Michael| last4 = Ponnambalam| first4 = Sreenivasan| last5 = Armstrong| first5 = John| last6 = Takamatsu| first6 = Haru-Hisa| last7 = Wileman| first7 = Thomas E.| pmid = 16956944| pmc = 1642160}} Individual GalNAc-transferases have distinct activities, and initiation of O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases.{{cite web | title = Entrez Gene: GALNT2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2590}}
References
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Further reading
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- {{cite journal |vauthors=Bennett EP, Hassan H, Clausen H |title=cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3. |journal=J. Biol. Chem. |volume=271 |issue= 29 |pages= 17006–12 |year= 1996 |pmid= 8663203 |doi=10.1074/jbc.271.29.17006 |doi-access=free }}
- {{cite journal |vauthors=Wandall HH, Hassan H, Mirgorodskaya E |title=Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23503–14 |year= 1997 |pmid= 9295285 |doi=10.1074/jbc.272.38.23503 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Müller S, Goletz S, Packer N |title=Localization of O-glycosylation sites on glycopeptide fragments from lactation-associated MUC1. All putative sites within the tandem repeat are glycosylation targets in vivo. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 24780–93 |year= 1997 |pmid= 9312074 |doi=10.1074/jbc.272.40.24780 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Röttger S, White J, Wandall HH |title=Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus. |journal=J. Cell Sci. |volume=111 |issue= 1|pages= 45–60 |year= 1998 |doi=10.1242/jcs.111.1.45 |pmid= 9394011 |display-authors=etal}}
- {{cite journal |vauthors=Mattu TS, Pleass RJ, Willis AC |title=The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2260–72 |year= 1998 |pmid= 9442070 |doi=10.1074/jbc.273.4.2260 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Iwasaki H, Zhang Y, Tachibana K |title=Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 5613–21 |year= 2003 |pmid= 12438318 |doi= 10.1074/jbc.M211097200 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Marcos NT, Cruz A, Silva F |title=Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines |journal=J. Histochem. Cytochem. |volume=51 |issue= 6 |pages= 761–71 |year= 2003 |pmid= 12754287 |doi=10.1177/002215540305100607 |display-authors=etal|doi-access= |s2cid=16133163 }}
- {{cite journal |vauthors=Kinarsky L, Suryanarayanan G, Prakash O |title=Conformational studies on the MUC1 tandem repeat glycopeptides: implication for the enzymatic O-glycosylation of the mucin protein core |journal=Glycobiology |volume=13 |issue= 12 |pages= 929–39 |year= 2004 |pmid= 12925576 |doi= 10.1093/glycob/cwg109 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |display-authors=etal|doi-access=free }}
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