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GALNT3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox gene}}

Polypeptide N-acetylgalactosaminyltransferase 3 is an enzyme that in humans is encoded by the GALNT3 gene.{{cite journal |vauthors=Bennett EP, Weghuis DO, Merkx G, van Kessel AG, Eiberg H, Clausen H | title = Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family | journal = Glycobiology | volume = 8 | issue = 6 | pages = 547–55 |date=Jul 1998 | pmid = 9592121 | doi =10.1093/glycob/8.6.547 | doi-access = free }}{{cite journal |vauthors=Topaz O, Shurman DL, Bergman R, Indelman M, Ratajczak P, Mizrachi M, Khamaysi Z, Behar D, Petronius D, Friedman V, Zelikovic I, Raimer S, Metzker A, Richard G, Sprecher E | title = Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis | journal = Nat Genet | volume = 36 | issue = 6 | pages = 579–81 |date=May 2004 | pmid = 15133511 | doi = 10.1038/ng1358 | doi-access = free }}{{cite web | title = Entrez Gene: GALNT3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2591}}

This gene encodes UDP-GalNAc transferase 3, a member of the polypeptide GalNAc transferase (GalNAc-T) family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members; however, the enzymes have different substrate specificities.

References

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Further reading

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  • {{cite journal |vauthors=Bennett EP, Hassan H, Clausen H |title=cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3 |journal=J. Biol. Chem. |volume=271 |issue= 29 |pages= 17006–12 |year= 1996 |pmid= 8663203 |doi=10.1074/jbc.271.29.17006 |doi-access=free }}
  • {{cite journal | author=Wandall HH |title=Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3 |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23503–14 |year= 1997 |pmid= 9295285 |doi=10.1074/jbc.272.38.23503 |name-list-style=vanc| author2=Hassan H | author3=Mirgorodskaya E | display-authors=3 | last4=Kristensen | first4=AK | last5=Roepstorff | first5=P | last6=Bennett | first6=EP | last7=Nielsen | first7=PA | last8=Hollingsworth | first8=MA | last9=Burchell | first9=J | doi-access=free }}
  • {{cite journal | author=Röttger S |title=Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus |journal=J. Cell Sci. |volume=111 |issue= 1|pages= 45–60 |year= 1998 |pmid= 9394011 |name-list-style=vanc| author2=White J | author3=Wandall HH | display-authors=3 | last4=Olivo | first4=JC | last5=Stark | first5=A | last6=Bennett | first6=EP | last7=Whitehouse | first7=C | last8=Berger | first8=EG | last9=Clausen | first9=H |doi=10.1242/jcs.111.1.45 }}
  • {{cite journal | author=Mandel U |title=Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family |journal=Glycobiology |volume=9 |issue= 1 |pages= 43–52 |year= 1999 |pmid= 9884405 |doi=10.1093/glycob/9.1.43 |name-list-style=vanc| author2=Hassan H | author3=Therkildsen MH | display-authors=3 | last4=Rygaard | first4=J | last5=Jakobsen | first5=MH | last6=Juhl | first6=BR | last7=Dabelsteen | first7=E | last8=Clausen | first8=H | doi-access=free }}
  • {{cite journal | author=Dosaka-Akita H |title=N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers |journal=Br. J. Cancer |volume=87 |issue= 7 |pages= 751–5 |year= 2002 |pmid= 12232759 |doi= 10.1038/sj.bjc.6600536 | pmc=2364253 |name-list-style=vanc| author2=Kinoshita I | author3=Yamazaki K | display-authors=3 | last4=Izumi | first4=H | last5=Itoh | first5=T | last6=Katoh | first6=H | last7=Nishimura | first7=M | last8=Matsuo | first8=K | last9=Yamada | first9=Y }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Argüeso P |title=The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 1 |pages= 86–92 |year= 2003 |pmid= 12506059 |doi=10.1167/iovs.02-0181 |name-list-style=vanc| author2=Tisdale A | author3=Mandel U | display-authors=3 | last4=Letko | first4=E | last5=Foster | first5=CS | last6=Gipson | first6=IK | doi-access=free }}
  • {{cite journal | author=Onitsuka K |title=Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma |journal=Cancer Sci. |volume=94 |issue= 1 |pages= 32–6 |year= 2003 |pmid= 12708471 |doi=10.1111/j.1349-7006.2003.tb01348.x |name-list-style=vanc| author2=Shibao K | author3=Nakayama Y | display-authors=3 | last4=Minagawa | first4=Noritaka | last5=Hirata | first5=Keiji | last6=Izumi | first6=Hiroto | last7=Matsuo | first7=Ken-Ichi | last8=Nagata | first8=Naoki | last9=Kitazato | first9=Kenji |s2cid=42340701 | doi-access=free | pmc=11160290 }}
  • {{cite journal | author=Yamamoto S |title=Expression of uridine diphosphate N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 3 in adenocarcinoma of the pancreas |journal=Pathobiology |volume=71 |issue= 1 |pages= 12–8 |year= 2004 |pmid= 14555840 |doi= 10.1159/000072957 |name-list-style=vanc| author2=Nakamori S | author3=Tsujie M | display-authors=3 | last4=Takahashi | first4=Yuji | last5=Nagano | first5=Hiroaki | last6=Dono | first6=Keizo | last7=Umeshita | first7=Koji | last8=Sakon | first8=Masato | last9=Tomita | first9=Yasuhiko |s2cid=20321446 }}
  • {{cite journal | author=Gu C |title=Low expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: impact on poor prognosis and early recurrence |journal=Br. J. Cancer |volume=90 |issue= 2 |pages= 436–42 |year= 2004 |pmid= 14735190 |doi= 10.1038/sj.bjc.6601531 | pmc=2409559 |name-list-style=vanc| author2=Oyama T | author3=Osaki T | display-authors=3 | last4=Li | first4=J | last5=Takenoyama | first5=M | last6=Izumi | first6=H | last7=Sugio | first7=K | last8=Kohno | first8=K | last9=Yasumoto | first9=K }}
  • {{cite journal | author=Miyahara N |title=Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase isozyme 3 in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder |journal=Clin. Cancer Res. |volume=10 |issue= 6 |pages= 2090–9 |year= 2004 |pmid= 15041730 |doi=10.1158/1078-0432.CCR-1024-03 |name-list-style=vanc| author2=Shoda J | author3=Kawamoto T | display-authors=3 | last4=Furukawa | first4=M | last5=Ueda | first5=T | last6=Todoroki | first6=T | last7=Tanaka | first7=N | last8=Matsuo | first8=K | last9=Yamada | first9=Y | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal |vauthors=Ishikawa M, Kitayama J, Kohno K, Nagawa H |title=The expression pattern of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetyl-galactosaminyl transferase-3 in squamous cell carcinoma of the esophagus |journal=Pathobiology |volume=72 |issue= 3 |pages= 139–45 |year= 2005 |pmid= 15860931 |doi= 10.1159/000084117 |s2cid=33360750 }}
  • {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
  • {{cite journal | author=Kato K |title=Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation |journal=J. Biol. Chem. |volume=281 |issue= 27 |pages= 18370–7 |year= 2006 |pmid= 16638743 |doi= 10.1074/jbc.M602469200 |name-list-style=vanc| author2=Jeanneau C | author3=Tarp MA | display-authors=3 | last4=Benet-Pagès | first4=A | last5=Lorenz-Depiereux | first5=B | last6=Bennett | first6=EP | last7=Mandel | first7=U | last8=Strom | first8=TM | last9=Clausen | first9=H | doi-access=free }}
  • {{cite journal | author=Ichikawa S |title=Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase domain of the GALNT3 gene |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 11 |pages= 4472–5 |year= 2007 |pmid= 16940445 |doi= 10.1210/jc.2006-1247 |name-list-style=vanc| author2=Imel EA | author3=Sorenson AH | display-authors=3 | last4=Severe | first4=R. | last5=Knudson | first5=P. | last6=Harris | first6=G. J. | last7=Shaker | first7=J. L. | last8=Econs | first8=M. J. | doi-access=free }}
  • {{cite journal |vauthors=Barbieri AM, Filopanti M, Bua G, Beck-Peccoz P |title=Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis |journal=J. Hum. Genet. |volume=52 |issue= 5 |pages= 464–8 |year= 2007 |pmid= 17351710 |doi= 10.1007/s10038-007-0126-5 |doi-access= free }}
  • {{cite journal | author=Inoue T |title=Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections - special reference to its association with lymph node metastases- |journal=Mod. Pathol. |volume=20 |issue= 2 |pages= 267–76 |year= 2007 |pmid= 17361208 |doi= 10.1038/modpathol.3800700 |name-list-style=vanc| author2=Eguchi T | author3=Oda Y | display-authors=3 | last4=Nishiyama | first4=Kenichi | last5=Fujii | first5=Kei | last6=Izumi | first6=Hiroto | last7=Kohno | first7=Kimitoshi | last8=Yamaguchi | first8=Koji | last9=Tanaka | first9=Masao | doi-access=free }}

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