GAS7
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Growth arrest-specific protein 7 is a protein that in humans is encoded by the GAS7 gene.{{cite journal |vauthors=Ju YT, Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S | title = gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 19 | pages = 11423–11428 |date=Oct 1998 | pmid = 9736752 | pmc = 21658 | doi =10.1073/pnas.95.19.11423 | bibcode = 1998PNAS...9511423J | doi-access = free }}{{cite web | title = Entrez Gene: GAS7 growth arrest-specific 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8522| accessdate = }}
Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.
References
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Further reading
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- {{cite journal |vauthors=Kurtz A, Zimmer A |title=Interspecies fluorescence in situ hybridization further defines synteny homology between mouse chromosome 11 and human chromosome 17 |journal=Mamm. Genome |volume=6 |issue= 5 |pages= 379–380 |year= 1995 |pmid= 7626897 |doi=10.1007/BF00364810 |s2cid=32467578 |url=https://zenodo.org/record/1232432 }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–174 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–156 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-style=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }}
- {{cite journal | author=Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=4 |issue= 5 |pages= 307–313 |year= 1998 |pmid= 9455477 |doi=10.1093/dnares/4.5.307 |name-list-style=vanc| author2=Nagase T | author3=Nakajima D | display-authors=3 | last4=Seki | first4=N | last5=Ohira | first5=M | last6=Miyajima | first6=N | last7=Tanaka | first7=A | last8=Kotani | first8=H | last9=Nomura | first9=N | doi-access=free }}
- {{cite journal | author=Megonigal MD |title=Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2814–2819 |year= 2000 |pmid= 10706619 |doi= 10.1073/pnas.050397097 | pmc=16012 |name-list-style=vanc| author2=Cheung NK | author3=Rappaport EF | display-authors=3 | last4=Nowell | first4=PC | last5=Wilson | first5=RB | last6=Jones | first6=DH | last7=Addya | first7=K | last8=Leonard | first8=DG | last9=Kushner | first9=BH |bibcode=2000PNAS...97.2814M |doi-access=free }}
- {{cite journal |vauthors=She BR, Liou GG, Lin-Chao S |title=Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth |journal=Exp. Cell Res. |volume=273 |issue= 1 |pages= 34–44 |year= 2002 |pmid= 11795944 |doi= 10.1006/excr.2001.5435 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal |vauthors=Chao CC, Chang PY, Lu HH |title=Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth |journal=J. Neurosci. Res. |volume=81 |issue= 2 |pages= 153–162 |year= 2005 |pmid= 15948147 |doi= 10.1002/jnr.20552 |s2cid=9789678 |doi-access=free }}
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