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GCFC2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

GC-rich sequence DNA-binding factor is a protein that in humans is encoded by the GCFC2 gene.{{cite journal | vauthors = Johnson AC, Kageyama R, Popescu NC, Pastan I | title = Expression and chromosomal localization of the gene for the human transcriptional repressor GCF | journal = J Biol Chem | volume = 267 | issue = 3 | pages = 1689–94 |date=Feb 1992 | doi = 10.1016/S0021-9258(18)46000-0 | pmid = 1370479 | doi-access = free }}{{cite journal | vauthors = Kageyama R, Pastan I | title = Molecular cloning and characterization of a human DNA binding factor that represses transcription | journal = Cell | volume = 59 | issue = 5 | pages = 815–25 |date=Jan 1990 | pmid = 2556218 | doi =10.1016/0092-8674(89)90605-3 | s2cid = 21177070 }}{{cite journal | vauthors = Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, Massinen S, Onkamo P, Warnke A, Griesemann H, Hoffmann P, Nopola-Hemmi J, Lyytinen H, Schulte-Korne G, Kere J, Nothen MM, Peyrard-Janvid M | title = A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia | journal = Hum Mol Genet | volume = 16 | issue = 6 | pages = 667–77 |date=Apr 2007 | pmid = 17309879 | doi = 10.1093/hmg/ddm009 }}{{cite web | title = Entrez Gene: C2orf3 chromosome 2 open reading frame 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6936}}

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.

References

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External links

  • {{UCSC gene info|GCFC2}}

Further reading

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  • {{cite journal | author=Mao P |title=[Revisions of the cDNA and primary protein structure of human transcription factor GCF] |journal=Hokkaido Igaku Zasshi |volume=74 |issue= 4 |pages= 315–30 |year= 1999 |pmid= 10480038 }}
  • {{cite journal | vauthors=Takimoto M, Mao P, Wei G |title=Molecular analysis of the GCF gene identifies revisions to the cDNA and amino acid sequences(1) |journal=Biochim. Biophys. Acta |volume=1447 |issue= 1 |pages= 125–31 |year= 1999 |pmid= 10500253 |doi= 10.1016/S0167-4781(99)00127-X|display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}

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