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GCNT1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the GCNT1 gene.{{cite journal |vauthors=Bierhuizen MF, Mattei MG, Fukuda M | title = Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family | journal = Genes Dev | volume = 7 | issue = 3 | pages = 468–78 |date=Apr 1993 | pmid = 8449405 | doi =10.1101/gad.7.3.468 | doi-access = free }}{{cite journal |vauthors=Yeh JC, Ong E, Fukuda M | title = Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches | journal = J Biol Chem | volume = 274 | issue = 5 | pages = 3215–21 |date=Mar 1999 | pmid = 9915862 | doi =10.1074/jbc.274.5.3215 | doi-access = free }}{{cite web | title = Entrez Gene: GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2650}}

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References

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Further reading

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  • {{cite journal |vauthors=Bierhuizen MF, Fukuda M |title=Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 19 |pages= 9326–330 |year= 1992 |pmid= 1329093 |doi=10.1073/pnas.89.19.9326 | pmc=50119 |bibcode=1992PNAS...89.9326B |doi-access=free }}
  • {{cite journal |vauthors=Bierhuizen MF, Maemura K, Kudo S, Fukuda M |title=Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1,6-N-acetylglucosaminyltransferase gene family. |journal=Glycobiology |volume=5 |issue= 4 |pages= 417–25 |year= 1995 |pmid= 7579796 |doi=10.1093/glycob/5.4.417 }}
  • {{cite journal |vauthors=Skrincosky D, Kain R, El-Battari A |title=Altered Golgi localization of core 2 beta-1,6-N-acetylglucosaminyltransferase leads to decreased synthesis of branched O-glycans. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22695–702 |year= 1997 |pmid= 9278427 |doi=10.1074/jbc.272.36.22695 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Beum PV, Bastola DR, Cheng PW |title=Mucin biosynthesis: epidermal growth factor downregulates core 2 enzymes in a human airway adenocarcinoma cell line. |journal=Am. J. Respir. Cell Mol. Biol. |volume=29 |issue= 1 |pages= 48–56 |year= 2003 |pmid= 12600830 |doi= 10.1165/rcmb.2002-0147OC }}
  • {{cite journal |vauthors=Falkenberg VR, Alvarez K, Roman C, Fregien N |title=Multiple transcription initiation and alternative splicing in the 5' untranslated region of the core 2 beta1-6 N-acetylglucosaminyltransferase I gene. |journal=Glycobiology |volume=13 |issue= 6 |pages= 411–8 |year= 2004 |pmid= 12626388 |doi= 10.1093/glycob/cwg039 |doi-access= free }}
  • {{cite journal |vauthors=Chibber R, Ben-Mahmud BM, Mann GE |title=Protein kinase C beta2-dependent phosphorylation of core 2 GlcNAc-T promotes leukocyte-endothelial cell adhesion: a mechanism underlying capillary occlusion in diabetic retinopathy. |journal=Diabetes |volume=52 |issue= 6 |pages= 1519–27 |year= 2003 |pmid= 12765965 |doi=10.2337/diabetes.52.6.1519 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Smith MJ, Smith BR, Lawrence MB, Snapp KR |title=Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 in rolling on P-selectin. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 21984–91 |year= 2004 |pmid= 15026421 |doi= 10.1074/jbc.M402731200 |doi-access= free }}
  • {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |display-authors=etal}}
  • {{cite journal |vauthors=Kikuchi J, Shinohara H, Nonomura C |title=Not core 2 beta 1,6-N-acetylglucosaminyltransferase-2 or -3 but -1 regulates sialyl-Lewis x expression in human precursor B cells. |journal=Glycobiology |volume=15 |issue= 3 |pages= 271–80 |year= 2005 |pmid= 15483269 |doi= 10.1093/glycob/cwi005 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Beum PV, Basma H, Bastola DR, Cheng PW |title=Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=288 |issue= 1 |pages= L116–24 |year= 2005 |pmid= 15591039 |doi= 10.1152/ajplung.00370.2003 }}
  • {{cite journal |vauthors=Wang L, Mitoma J, Tsuchiya N |title=An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 4 |pages= 958–63 |year= 2005 |pmid= 15882971 |doi= 10.1016/j.bbrc.2005.04.022 |display-authors=etal}}
  • {{cite journal |vauthors=Prorok-Hamon M, Notel F, Mathieu S |title=N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding. |journal=Biochem. J. |volume=391 |issue= Pt 3 |pages= 491–502 |year= 2006 |pmid= 15926890 |doi= 10.1042/BJ20050344 | pmc=1276950 |display-authors=etal}}
  • {{cite journal |vauthors=Hagisawa S, Ohyama C, Takahashi T |title=Expression of core 2 beta1,6-N-acetylglucosaminyltransferase facilitates prostate cancer progression. |journal=Glycobiology |volume=15 |issue= 10 |pages= 1016–24 |year= 2006 |pmid= 15932919 |doi= 10.1093/glycob/cwi086 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Kikuchi J, Ozaki H, Nonomura C |title=Transfection of antisense core 2 beta1,6-N-acetylglucosaminyltransferase-1 cDNA suppresses selectin ligand expression and tissue infiltration of B-cell precursor leukemia cells. |journal=Leukemia |volume=19 |issue= 11 |pages= 1934–40 |year= 2005 |pmid= 16179912 |doi= 10.1038/sj.leu.2403951 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
  • {{cite journal |vauthors=Cabrera PV, Amano M, Mitoma J |title=Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death. |journal=Blood |volume=108 |issue= 7 |pages= 2399–406 |year= 2006 |pmid= 16778138 |doi= 10.1182/blood-2006-04-018556 | pmc=1895562 |display-authors=etal}}
  • {{cite journal |vauthors=Julien S, Grimshaw MJ, Sutton-Smith M |title=Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I. |journal=J. Immunol. |volume=179 |issue= 9 |pages= 5701–10 |year= 2007 |pmid= 17947642 |doi= 10.4049/jimmunol.179.9.5701|display-authors=etal|doi-access=free }}

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