GDF10
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.{{cite journal |vauthors=Cunningham NS, Jenkins NA, Gilbert DJ, Copeland NG, Reddi AH, Lee SJ | title = Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3 | journal = Growth Factors | volume = 12 | issue = 2 | pages = 99–109 | year = 1995 | pmid = 8679252 | doi = 10.3109/08977199509028956}}
GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis.{{cite journal |vauthors=Hino J, Kangawa K, Matsuo H, Nohno T, Nishimatsu S |title=Bone morphogenetic protein-3 family members and their biological functions |journal=Front Biosci |volume=9 |issue= 1–3|pages=1520–9 |year= 2004|pmid=14977563 |doi=10.2741/1355|doi-access=free }} GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.
In mice, GDF10 mRNA is abundant in the brain, inner ear, uterus, prostate, neural tissues, blood vessels and adipose tissue with low expression in spleen and liver. It is also present in bone of both adults and neonatal mice. Human GDF10 mRNA is found in the cochlea and lung of foetuses, and in testis, retina, pineal gland, and other neural tissues of adults.{{cite journal |vauthors=Katoh Y, Katoh M |title=Comparative integromics on BMP/GDF family |journal=Int J Mol Med |volume=17 |issue=5 |pages=951–5 |year=2006 |pmid=16596286 |doi=10.3892/ijmm.17.5.951|doi-access=free }}
References
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Further reading
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- {{cite journal |vauthors=Davila S, Froeling FE, Tan A |title=New genetic associations detected in a host response study to hepatitis B vaccine. |journal=Genes Immun. |volume=11 |issue= 3 |pages= 232–8 |year= 2010 |pmid= 20237496 |doi= 10.1038/gene.2010.1 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Ducy P, Karsenty G |title=The family of bone morphogenetic proteins. |journal=Kidney Int. |volume=57 |issue= 6 |pages= 2207–14 |year= 2000 |pmid= 10844590 |doi= 10.1046/j.1523-1755.2000.00081.x |doi-access= free }}
- {{cite journal |vauthors=Grupe A, Li Y, Rowland C |title=A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. |journal=Am. J. Hum. Genet. |volume=78 |issue= 1 |pages= 78–88 |year= 2006 |pmid= 16385451 |doi= 10.1086/498851 |pmc=1380225 |display-authors=etal}}
- {{cite journal |vauthors=Hino J, Takao M, Takeshita N |title=cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b). |journal=Biochem. Biophys. Res. Commun. |volume=223 |issue= 2 |pages= 304–10 |year= 1996 |pmid= 8670277 |doi= 10.1006/bbrc.1996.0889 |display-authors=etal}}
- {{cite journal |vauthors=Zhou M, Lucas DA, Chan KC |title=An investigation into the human serum "interactome". |journal=Electrophoresis |volume=25 |issue= 9 |pages= 1289–98 |year= 2004 |pmid= 15174051 |doi= 10.1002/elps.200405866 |s2cid=42449980 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Kimura K, Toyooka S, Tsukuda K |title=The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas. |journal=Oncol. Rep. |volume=20 |issue= 5 |pages= 1265–8 |year= 2008 |pmid= 18949431 |doi= 10.3892/or_00000139 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Lafont JE, Talma S, Hopfgarten C, Murphy CL |title=Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways. |journal=J. Biol. Chem. |volume=283 |issue= 8 |pages= 4778–86 |year= 2008 |pmid= 18077449 |doi= 10.1074/jbc.M707729200 |doi-access= free }}
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{{TGF beta signaling}}
{{TGFβ receptor superfamily modulators}}
Category:Developmental genes and proteins
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