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GDI2

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{{Short description|Protein-coding gene in the species Homo sapiens}}

{{for|the chemical compound with formula GdI2|Gadolinium diiodide}}

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Rab GDP dissociation inhibitor beta is a protein that in humans is encoded by the GDI2 gene.{{cite journal |vauthors=Sedlacek Z, Munstermann E, Mincheva A, Lichter P, Poustka A | title = The human rab GDI beta gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13 | journal = Mamm Genome | volume = 9 | issue = 1 | pages = 78–80 |date=Feb 1998 | pmid = 9434952 | doi =10.1007/s003359900685 | s2cid = 36441100 }}{{cite web | title = Entrez Gene: GDI2 GDP dissociation inhibitor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2665}}

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements.

References

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Further reading

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  • {{cite journal |vauthors=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }}
  • {{cite journal |vauthors=Shisheva A, Südhof TC, Czech MP |title=Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. |journal=Mol. Cell. Biol. |volume=14 |issue= 5 |pages= 3459–68 |year= 1994 |pmid= 7513052 |doi= 10.1128/mcb.14.5.3459| pmc=358710 }}
  • {{cite journal |vauthors=Bächner D, Sedlacek Z, Korn B |title=Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport. |journal=Hum. Mol. Genet. |volume=4 |issue= 4 |pages= 701–8 |year= 1995 |pmid= 7543319 |doi=10.1093/hmg/4.4.701 |display-authors=etal}}
  • {{cite journal |vauthors=Nishimura N, Goji J, Nakamura H |title=Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens. |journal=Cancer Res. |volume=55 |issue= 22 |pages= 5445–50 |year= 1995 |pmid= 7585614 |display-authors=etal}}
  • {{cite journal |vauthors=Shisheva A, Buxton J, Czech MP |title=Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes. |journal=J. Biol. Chem. |volume=269 |issue= 39 |pages= 23865–8 |year= 1994 |doi=10.1016/S0021-9258(19)51016-X |pmid= 7929030 |doi-access=free }}
  • {{cite journal |vauthors=Shisheva A, Doxsey SJ, Buxton JM, Czech MP |title=Pericentriolar targeting of GDP-dissociation inhibitor isoform 2. |journal=Eur. J. Cell Biol. |volume=68 |issue= 2 |pages= 143–58 |year= 1996 |pmid= 8575461 }}
  • {{cite journal |vauthors=Shisheva A, Chinni SR, DeMarco C |title=General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. |journal=Biochemistry |volume=38 |issue= 36 |pages= 11711–21 |year= 1999 |pmid= 10512627 |doi=10.1021/bi990200r }}
  • {{cite journal |vauthors=Caillol N, Pasqualini E, Lloubes R, Lombardo D |title=Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. |journal=J. Cell. Biochem. |volume=79 |issue= 4 |pages= 628–47 |year= 2000 |pmid= 10996854 |doi=10.1002/1097-4644(20001215)79:4<628::AID-JCB120>3.0.CO;2-T |s2cid=11614620 }}
  • {{cite book |vauthors=Weitzdoerfer R, Stolzlechner D, Dierssen M |chapter=Reduction of nucleoside diphosphate kinase B, Rab GDP- dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down Syndrome brain |title=Protein Expression in Down Syndrome Brain |journal=Journal of Neural Transmission. Supplementum |issue= 61 |pages= 347–59 |year= 2002 |pmid= 11771757 |doi= 10.1007/978-3-7091-6262-0_29|isbn=978-3-211-83704-7 |display-authors=etal}}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Shin BK, Wang H, Yim AM |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607–16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Theodorescu D, Sapinoso LM, Conaway MR |title=Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 11 |pages= 3800–6 |year= 2004 |pmid= 15173088 |doi= 10.1158/1078-0432.CCR-03-0653 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal |vauthors=Bruneel A, Labas V, Mailloux A |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |journal=Proteomics |volume=5 |issue= 15 |pages= 3876–84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239 |s2cid=26007149 |display-authors=etal}}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
  • {{cite journal |vauthors=Hu LD, Zou HF, Zhan SX, Cao KM |title=Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis. |journal=Oncol. Rep. |volume=17 |issue= 6 |pages= 1383–9 |year= 2007 |pmid= 17487395 |doi= 10.3892/or.17.6.1383|doi-access=free }}
  • {{cite journal |vauthors=Sun ZL, Zhu Y, Wang FQ |title=Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. |journal=Biochim. Biophys. Acta |volume=1774 |issue= 6 |pages= 764–71 |year= 2007 |pmid= 17507299 |doi= 10.1016/j.bbapap.2007.04.001 |display-authors=etal}}

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