GEMIN8

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene.{{cite web | title = Entrez Gene: gem (nuclear organelle) associated protein 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54960}}{{cite journal |vauthors=Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L | title = Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly | journal = J. Biol. Chem. | volume = 281 | issue = 12 | pages = 8126–34 |date=March 2006 | pmid = 16434402 | doi = 10.1074/jbc.M512243200 | doi-access = free }}

Function

Gemin-8 is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. Gemin-8 binds to both SMN1 and the GEMIN6 / GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.

References

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Further reading

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  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Carissimi C, Saieva L, Gabanella F, Pellizzoni L |title=Gemin8 is required for the architecture and function of the survival motor neuron complex. |journal=J. Biol. Chem. |volume=281 |issue= 48 |pages= 37009–16 |year= 2006 |pmid= 17023415 |doi= 10.1074/jbc.M607505200 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}

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{{Nucleus}}

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