GFPT1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Glucosamine—fructose-6-phosphate aminotransferase isomerizing 1 is an enzyme that in humans is encoded by the GFPT1 gene.{{cite journal |vauthors=McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ | title = Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase | journal = J Biol Chem | volume = 267 | issue = 35 | pages = 25208–12 |date=Jan 1993 | doi = 10.1016/S0021-9258(19)74026-5 | pmid = 1460020 | doi-access = free }}{{cite web | title = Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2673}}

Glutamine-fructose-6-phosphate transaminase 1 is the first and rate-limiting enzyme of the hexosamine pathway. GFAT controls the flux of glucose into the hexosamine pathway and catalyzes the formation of glucosamine 6-phosphate.

References

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Further reading

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  • {{cite journal |vauthors=Schleicher ED, Weigert C |title=Role of the hexosamine biosynthetic pathway in diabetic nephropathy |journal=Kidney Int. Suppl. |volume=77 |pages= S13–8 |year= 2001 |pmid= 10997685 |doi= 10.1046/j.1523-1755.2000.07703.x|doi-access=free }}
  • {{cite journal |vauthors=Traxinger RR, Marshall S |title=Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10148–54 |year= 1991 |doi=10.1016/S0021-9258(18)99202-1 |pmid= 2037571 |doi-access=free }}
  • {{cite journal |vauthors=Whitmore TE, Mudri SL, McKnight GL |title=Physical mapping of the human glutamine:fructose-6-phosphate amidotransferase gene (GFPT) to chromosome 2p13 |journal=Genomics |volume=26 |issue= 2 |pages= 422–3 |year= 1995 |pmid= 7601477 |doi=10.1016/0888-7543(95)80235-E }}
  • {{cite journal | author=Zhou J |title=Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13 |journal=Hum. Genet. |volume=96 |issue= 1 |pages= 99–101 |year= 1995 |pmid= 7607664 |doi=10.1007/BF00214194 |name-list-style=vanc| author2=Neidigh JL | author3=Espinosa R | display-authors=3 | last4=Lebeau | first4=Michelle M. | last5=McClain | first5=Donald A. |s2cid=25484995 }}
  • {{cite journal |vauthors=Sayeski PP, Paterson AJ, Kudlow JE |title=The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence |journal=Gene |volume=140 |issue= 2 |pages= 289–90 |year= 1994 |pmid= 8144040 |doi=10.1016/0378-1119(94)90560-6 }}
  • {{cite journal | author=Nerlich AG |title=Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes |journal=Diabetes |volume=47 |issue= 2 |pages= 170–8 |year= 1998 |pmid= 9519709 |doi=10.2337/diabetes.47.2.170 |name-list-style=vanc| author2=Sauer U | author3=Kolm-Litty V | display-authors=3 | last4=Wagner | first4=E. | last5=Koch | first5=M. | last6=Schleicher | first6=E. D. }}
  • {{cite journal | author=Oki T |title=cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse |journal=Genomics |volume=57 |issue= 2 |pages= 227–34 |year= 1999 |pmid= 10198162 |doi= 10.1006/geno.1999.5785 |name-list-style=vanc| author2=Yamazaki K | author3=Kuromitsu J | display-authors=3 | last4=Okada | first4=M | last5=Tanaka | first5=I }}
  • {{cite journal | author=Chang Q |title=Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 21981–7 |year= 2000 |pmid= 10806197 |doi= 10.1074/jbc.M001049200 |name-list-style=vanc| author2=Su K | author3=Baker JR | display-authors=3 | last4=Yang | first4=X | last5=Paterson | first5=AJ | last6=Kudlow | first6=JE | doi-access=free}}
  • {{cite journal | author=Niimi M |title=Identification of GFAT1-L, a novel splice variant of human glutamine: fructose-6-phosphate amidotransferase (GFAT1) that is expressed abundantly in skeletal muscle |journal=J. Hum. Genet. |volume=46 |issue= 10 |pages= 566–71 |year= 2001 |pmid= 11587069 |doi=10.1007/s100380170022 |name-list-style=vanc| author2=Ogawara T | author3=Yamashita T | display-authors=3 | last4=Yamamoto | first4=Y. | last5=Ueyama | first5=A. | last6=Kambe | first6=T. | last7=Okamoto | first7=T. | last8=Ban | first8=T. | last9=Tamanoi | first9=H. | doi-access=free }}
  • {{cite journal |vauthors=DeHaven JE, Robinson KA, Nelson BA, Buse MG |title=A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle |journal=Diabetes |volume=50 |issue= 11 |pages= 2419–24 |year= 2001 |pmid= 11679416 |doi=10.2337/diabetes.50.11.2419 |doi-access=free }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Weigert C |title=Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells |journal=Diabetologia |volume=46 |issue= 6 |pages= 852–5 |year= 2004 |pmid= 12802498 |doi= 10.1007/s00125-003-1122-8 |name-list-style=vanc| author2=Friess U | author3=Brodbeck K | display-authors=3 | last4=Häring | first4=H. U. | last5=Schleicher | first5=E. D. |doi-access=free }}
  • {{cite journal | author=Ng DP |title=Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy |journal=Diabetes |volume=53 |issue= 3 |pages= 865–9 |year= 2004 |pmid= 14988277 |doi=10.2337/diabetes.53.3.865 |name-list-style=vanc| author2=Walker WH | author3=Chia KS | display-authors=3 | last4=Choo | first4=S. | last5=Warram | first5=J. H. | last6=Krolewski | first6=A. S. | doi-access=free }}
  • {{cite journal | author=Elbein SC |title=Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy |journal=Mol. Genet. Metab. |volume=82 |issue= 4 |pages= 321–8 |year= 2005 |pmid= 15308130 |doi= 10.1016/j.ymgme.2004.05.004 |name-list-style=vanc| author2=Zheng H | author3=Jia Y | display-authors=3 | last4=Chu | first4=Winston | last5=Cooper | first5=Judith J. | last6=Hale | first6=Terri | last7=Zhang | first7=Zhengxian }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Chou KC |title=Molecular therapeutic target for type-2 diabetes |journal=J. Proteome Res. |volume=3 |issue= 6 |pages= 1284–8 |year= 2005 |pmid= 15595739 |doi= 10.1021/pr049849v }}
  • {{cite journal | author=Weigert C |title=The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 3 |pages= 1639–43 |year= 2005 |pmid= 15613432 |doi= 10.1210/jc.2004-0058 |name-list-style=vanc| author2=Thamer C | author3=Brodbeck K | display-authors=3 | last4=Guirguis | first4=A | last5=Machicao | first5=F | last6=Machann | first6=J | last7=Schick | first7=F | last8=Stumvoll | first8=M | last9=Fritsche | first9=A | doi-access=free }}
  • {{cite journal | author=Burt D |title=Partial characterisation of the human GFAT promoter: effect of single nucleotide polymorphisms on promoter function |journal=Biochim. Biophys. Acta |volume=1740 |issue= 1 |pages= 85–90 |year= 2005 |pmid= 15878746 |doi= 10.1016/j.bbadis.2005.01.007 |name-list-style=vanc| author2=Brodbeck K | author3=Häring HU | display-authors=3 | last4=Schleicher | first4=Erwin D. | last5=Weigert | first5=Cora |doi-access=free }}

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