GFRA1

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.{{cite web | title = Entrez Gene: GFRA1 GDNF family receptor alpha 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2674}}

GDNF family receptor alpha 1 has been shown to interact with GDNF{{cite journal | vauthors = Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM | title = GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 33111–7 | date = Dec 1997 | pmid = 9407096 | doi = 10.1074/jbc.272.52.33111 | doi-access = free }}{{cite journal | vauthors = Cik M, Masure S, Lesage AS, Van Der Linden I, Van Gompel P, Pangalos MN, Gordon RD, Leysen JE | title = Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions | journal = The Journal of Biological Chemistry | volume = 275 | issue = 36 | pages = 27505–12 | date = Sep 2000 | pmid = 10829012 | doi = 10.1074/jbc.M000306200 | doi-access = free }} and RET proto-oncogene.{{cite journal | vauthors = Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A | title = A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor | journal = Nature | volume = 387 | issue = 6634 | pages = 717–21 | date = Jun 1997 | pmid = 9192898 | doi = 10.1038/42722 | bibcode = 1997Natur.387..717K | s2cid = 4360246 | doi-access = free }}

• GFRα

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• {{cite journal | vauthors = Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, Asai N, Takahashi M, Vandlen R, Henderson CE, Rosenthal A | title = Characterization of a multicomponent receptor for GDNF | journal = Nature | volume = 382 | issue = 6586 | pages = 80–3 | date = Jul 1996 | pmid = 8657309 | doi = 10.1038/382080a0 | bibcode = 1996Natur.382...80T | s2cid = 4253979 }}
• {{cite journal | vauthors = Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis JC, Hu S, Altrock BW, Fox GM | title = GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF | journal = Cell | volume = 85 | issue = 7 | pages = 1113–24 | date = Jun 1996 | pmid = 8674117 | doi = 10.1016/S0092-8674(00)81311-2 | s2cid = 1724567 | doi-access = free }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Gattei V, Celetti A, Cerrato A, Degan M, De Iuliis A, Rossi FM, Chiappetta G, Consales C, Improta S, Zagonel V, Aldinucci D, Agosti V, Santoro M, Vecchio G, Pinto A, Grieco M | title = Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment | journal = Blood | volume = 89 | issue = 8 | pages = 2925–37 | date = Apr 1997 | pmid = 9108413 }}
• {{cite journal | vauthors = Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL | title = Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 12 | pages = 6238–43 | date = Jun 1997 | pmid = 9177201 | pmc = 21033 | doi = 10.1073/pnas.94.12.6238 | bibcode = 1997PNAS...94.6238S | doi-access = free }}
• {{cite journal | vauthors = Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM, Milbrandt J | title = TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret | journal = Neuron | volume = 18 | issue = 5 | pages = 793–802 | date = May 1997 | pmid = 9182803 | doi = 10.1016/S0896-6273(00)80318-9 | doi-access = free }}
• {{cite journal | vauthors = Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A | title = A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor | journal = Nature | volume = 387 | issue = 6634 | pages = 717–21 | date = Jun 1997 | pmid = 9192898 | doi = 10.1038/42722 | bibcode = 1997Natur.387..717K | s2cid = 4360246 | doi-access = free }}
• {{cite journal | vauthors = Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM | title = GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 33111–7 | date = Dec 1997 | pmid = 9407096 | doi = 10.1074/jbc.272.52.33111 | doi-access = free }}
• {{cite journal | vauthors = Eng C, Myers SM, Kogon MD, Sanicola M, Hession C, Cate RL, Mulligan LM | title = Genomic structure and chromosomal localization of the human GDNFR-alpha gene | journal = Oncogene | volume = 16 | issue = 5 | pages = 597–601 | date = Feb 1998 | pmid = 9482105 | doi = 10.1038/sj.onc.1201573 | s2cid = 735754 | doi-access = }}
• {{cite journal | vauthors = Shefelbine SE, Khorana S, Schultz PN, Huang E, Thobe N, Hu ZJ, Fox GM, Jing S, Cote GJ, Gagel RF | title = Mutational analysis of the GDNF/RET-GDNFR alpha signaling complex in a kindred with vesicoureteral reflux | journal = Human Genetics | volume = 102 | issue = 4 | pages = 474–8 | date = Apr 1998 | pmid = 9600247 | doi = 10.1007/s004390050724 | s2cid = 5631327 }}
• {{cite journal | vauthors = Cacalano G, Fariñas I, Wang LC, Hagler K, Forgie A, Moore M, Armanini M, Phillips H, Ryan AM, Reichardt LF, Hynes M, Davies A, Rosenthal A | title = GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney | journal = Neuron | volume = 21 | issue = 1 | pages = 53–62 | date = Jul 1998 | pmid = 9697851 | pmc = 2710137 | doi = 10.1016/S0896-6273(00)80514-0 }}
• {{cite journal | vauthors = Enokido Y, de Sauvage F, Hongo JA, Ninkina N, Rosenthal A, Buchman VL, Davies AM | title = GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin | journal = Current Biology | volume = 8 | issue = 18 | pages = 1019–22 | date = Sep 1998 | pmid = 9740802 | doi = 10.1016/S0960-9822(07)00422-8 | doi-access = free | bibcode = 1998CBio....8.1019E }}
• {{cite journal | vauthors = Tansey MG, Baloh RH, Milbrandt J, Johnson EM | title = GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival | journal = Neuron | volume = 25 | issue = 3 | pages = 611–23 | date = Mar 2000 | pmid = 10774729 | doi = 10.1016/S0896-6273(00)81064-8 | doi-access = free }}
• {{cite journal | vauthors = Hase A, Suzuki H, Arahata K, Akazawa C | title = Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves | journal = Neuroscience Letters | volume = 269 | issue = 1 | pages = 55–7 | date = Jul 1999 | pmid = 10821644 | doi = 10.1016/S0304-3940(99)00419-X | hdl = 10271/1630 | s2cid = 54274004 | hdl-access = free }}
• {{cite journal | vauthors = Cik M, Masure S, Lesage AS, Van Der Linden I, Van Gompel P, Pangalos MN, Gordon RD, Leysen JE | title = Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions | journal = The Journal of Biological Chemistry | volume = 275 | issue = 36 | pages = 27505–12 | date = Sep 2000 | pmid = 10829012 | doi = 10.1074/jbc.M000306200 | doi-access = free }}
• {{cite journal | vauthors = Paratcha G, Ledda F, Baars L, Coulpier M, Besset V, Anders J, Scott R, Ibáñez CF | title = Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts | journal = Neuron | volume = 29 | issue = 1 | pages = 171–84 | date = Jan 2001 | pmid = 11182089 | doi = 10.1016/S0896-6273(01)00188-X | s2cid = 14757558 | url = https://hal.inrae.fr/hal-02683393/file/2001_Paratcha_Neuron_1.pdf }}
• {{cite journal | vauthors = Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C | title = Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma | journal = Oncogene | volume = 20 | issue = 17 | pages = 2161–70 | date = Apr 2001 | pmid = 11360200 | doi = 10.1038/sj.onc.1204289 | doi-access = free }}
• {{cite journal | vauthors = Japón MA, Urbano AG, Sáez C, Segura DI, Cerro AL, Diéguez C, Alvarez CV | title = Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 87 | issue = 4 | pages = 1879–84 | date = Apr 2002 | doi = 10.1210/jcem.87.4.8383 | pmid = 11932334 | doi-access = free }}

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• {{PDBe-KB2|P56159|GDNF family receptor alpha-1}}

{{PDB Gallery|geneid=2674}}

{{Growth factor receptor modulators}}