GFRA3

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the artemin ligand.

In mouse models of osteoarthritis, GFRα3 was upregulated in sensory nerves. Treating arthritic mice with monoclonal antibodies that bind to GFRα3 prevents artemin from binding there and signaling pain. Treated mice were able to use their limbs again two hours post-treatment.{{Cite web|last=Irving|first=Michael|date=2022-01-31|title="Pain pathway" a promising new drug target to treat osteoarthritis pain|url=https://newatlas.com/medical/osteoarthritis-pain-treatment-molecular-pathway/|access-date=2022-02-01|website=New Atlas|language=en-US}}

• GFRα

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• {{cite journal | vauthors = Wang X, Baloh RH, Milbrandt J, Garcia KC | title = Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors | journal = Structure | volume = 14 | issue = 6 | pages = 1083–92 | date = Jun 2006 | pmid = 16765900 | doi = 10.1016/j.str.2006.05.010 | doi-access = free }}
• {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | date = October 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
• {{cite journal | vauthors = Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C | title = Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma | journal = Oncogene | volume = 20 | issue = 17 | pages = 2161–70 | date = Apr 2001 | pmid = 11360200 | doi = 10.1038/sj.onc.1204289 | doi-access = free }}
• {{cite journal | vauthors = Onochie CI, Korngut LM, Vanhorne JB, Myers SM, Michaud D, Mulligan LM | title = Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease | journal = Journal of Medical Genetics | volume = 37 | issue = 9 | pages = 674–9 | date = Sep 2000 | pmid = 10978357 | pmc = 1734691 | doi = 10.1136/jmg.37.9.674 }}
• {{cite journal | vauthors = Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J | title = Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex | journal = Neuron | volume = 21 | issue = 6 | pages = 1291–302 | date = December 1998 | pmid = 9883723 | doi = 10.1016/S0896-6273(00)80649-2 | s2cid = 18633359 | doi-access = free }}
• {{cite journal | vauthors = Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM, Milbrandt J | title = GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 10 | pages = 5801–6 | date = May 1998 | pmid = 9576965 | pmc = 20460 | doi = 10.1073/pnas.95.10.5801 | bibcode = 1998PNAS...95.5801B | doi-access = free }}
• {{cite journal | vauthors = Masure S, Cik M, Pangalos MN, Bonaventure P, Verhasselt P, Lesage AS, Leysen JE, Gordon RD | title = Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3) | journal = European Journal of Biochemistry | volume = 251 | issue = 3 | pages = 622–30 | date = Feb 1998 | pmid = 9490034 | doi = 10.1046/j.1432-1327.1998.2510622.x | doi-access = free }}
• {{cite journal | vauthors = Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC | title = Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening | journal = Genomics | volume = 23 | issue = 1 | pages = 42–50 | date = September 1994 | pmid = 7829101 | doi = 10.1006/geno.1994.1457 }}

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{{PDB Gallery|geneid=2676}}

{{Growth factor receptor modulators}}

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