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GJA4

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Gap junction alpha-4 protein, also known as Connexin-37 or Cx37, is a protein that in humans is encoded by the GJA4 gene.{{cite journal | vauthors = Richard G, Smith LE, Bailey RA, Itin P, Hohl D, Epstein EH, DiGiovanna JJ, Compton JG, Bale SJ | title = Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis | journal = Nature Genetics | volume = 20 | issue = 4 | pages = 366–9 | date = December 1998 | pmid = 9843209 | doi = 10.1038/3840 | s2cid = 841727 }}{{cite journal | vauthors = Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC | title = Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein | journal = The Journal of Clinical Investigation | volume = 91 | issue = 3 | pages = 997–1004 | date = March 1993 | pmid = 7680674 | pmc = 288052 | doi = 10.1172/JCI116321 }}{{cite web | title = Entrez Gene: GJA4 gap junction protein, alpha 4, 37kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2701}} This protein, like other Connexin proteins, forms connections between cells known as gap junctions. Connexin 37 can be found in many tissues including the ovary,{{cite book | vauthors = Winterhager E, Kidder GM | title = Gap junction connexins in female reproductive organs: implications for women's reproductive health | journal = Human Reproduction Update | volume = 21 | issue = 3 | pages = 340–52 | date = May 2015 | pmid = 25667189 | doi = 10.1093/humupd/dmv007 }} heart,{{cite book | vauthors = Duffy HS, Fort AG, Spray DC | chapter = Cardiac connexins: genes to nexus | series= Advances in Cardiology | volume = 42 | pages = 1–17 | date = 2006 | pmid = 16646581 | doi = 10.1159/000092550 | isbn = 978-3-8055-8077-9 | title = Cardiovascular Gap Junctions }} and kidney.{{cite journal | vauthors = Hanner F, Sorensen CM, Holstein-Rathlou NH, Peti-Peterdi J | title = Connexins and the kidney | journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | volume = 298 | issue = 5 | pages = R1143–55 | date = May 2010 | pmid = 20164205 | pmc = 2867516 | doi = 10.1152/ajpregu.00808.2009 }}

References

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Further reading

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  • {{cite book|author1=Andrew L Harris |author2=Darren Locke | title = Connexins, A Guide | publisher = Springer | year = 2009 | location = New York | pages = 574 | url = https://www.springer.com/978-1-934115-46-6 | isbn = 978-1-934115-46-6}}
  • {{cite journal | vauthors = Beyer EC, Paul DL, Goodenough DA | title = Connexin family of gap junction proteins | journal = The Journal of Membrane Biology | volume = 116 | issue = 3 | pages = 187–94 | date = July 1990 | pmid = 2167375 | doi = 10.1007/BF01868459 | s2cid = 43264684 }}
  • {{cite journal | vauthors = Haefliger JA, Bruzzone R, Jenkins NA, Gilbert DJ, Copeland NG, Paul DL | title = Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping | journal = The Journal of Biological Chemistry | volume = 267 | issue = 3 | pages = 2057–64 | date = January 1992 | doi = 10.1016/S0021-9258(18)46052-8 | pmid = 1370487 | doi-access = free }}
  • {{cite journal | vauthors = Risek B, Guthrie S, Kumar N, Gilula NB | title = Modulation of gap junction transcript and protein expression during pregnancy in the rat | journal = The Journal of Cell Biology | volume = 110 | issue = 2 | pages = 269–82 | date = February 1990 | pmid = 1688855 | pmc = 2116004 | doi = 10.1083/jcb.110.2.269 }}
  • {{cite journal | vauthors = Willecke K, Jungbluth S, Dahl E, Hennemann H, Heynkes R, Grzeschik KH | title = Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes | journal = European Journal of Cell Biology | volume = 53 | issue = 2 | pages = 275–80 | date = December 1990 | pmid = 1964417 }}
  • {{cite journal | vauthors = Van Camp G, Coucke P, Speleman F, Van Roy N, Beyer EC, Oostra BA, Willems PJ | title = The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195 | journal = Genomics | volume = 30 | issue = 2 | pages = 402–3 | date = November 1995 | pmid = 8586454 }}
  • {{cite journal | vauthors = Krutovskikh V, Mironov N, Yamasaki H | title = Human connexin 37 is polymorphic but not mutated in tumours | journal = Carcinogenesis | volume = 17 | issue = 8 | pages = 1761–3 | date = August 1996 | pmid = 8761439 | doi = 10.1093/carcin/17.8.1761 | citeseerx = 10.1.1.610.8446 }}
  • {{cite journal | vauthors = Simon AM, Goodenough DA, Li E, Paul DL | title = Female infertility in mice lacking connexin 37 | journal = Nature | volume = 385 | issue = 6616 | pages = 525–9 | date = February 1997 | pmid = 9020357 | doi = 10.1038/385525a0 | bibcode = 1997Natur.385..525S | s2cid = 4363114 }}
  • {{cite journal | vauthors = Krenacs T, Rosendaal M | title = Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation | journal = The American Journal of Pathology | volume = 152 | issue = 4 | pages = 993–1004 | date = April 1998 | pmid = 9546360 | pmc = 1858239 }}
  • {{cite journal | vauthors = van Rijen HV, van Kempen MJ, Postma S, Jongsma HJ | title = Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells | journal = Cytokine | volume = 10 | issue = 4 | pages = 258–64 | date = April 1998 | pmid = 9617570 | doi = 10.1006/cyto.1997.0287 }}
  • {{cite journal | vauthors = Boerma M, Forsberg L, Van Zeijl L, Morgenstern R, De Faire U, Lemne C, Erlinge D, Thulin T, Hong Y, Cotgreave IA | title = A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development | journal = Journal of Internal Medicine | volume = 246 | issue = 2 | pages = 211–8 | date = August 1999 | pmid = 10447790 | doi = 10.1046/j.1365-2796.1999.00564.x | doi-access = free }}
  • {{cite journal | vauthors = Saito T, Krutovskikh V, Marion MJ, Ishak KG, Bennett WP, Yamasaki H | title = Human hemangiosarcomas have a common polymorphism but no mutations in the connexin37 gene | journal = International Journal of Cancer | volume = 86 | issue = 1 | pages = 67–70 | date = April 2000 | pmid = 10728596 | doi = 10.1002/(SICI)1097-0215(20000401)86:1<67::AID-IJC10>3.0.CO;2-1 | doi-access = free }}
  • {{cite journal | vauthors = Suzuki Y, Taira H, Tsunoda T, Mizushima-Sugano J, Sese J, Hata H, Ota T, Isogai T, Tanaka T, Morishita S, Okubo K, Sakaki Y, Nakamura Y, Suyama A, Sugano S | title = Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites | journal = EMBO Reports | volume = 2 | issue = 5 | pages = 388–93 | date = May 2001 | pmid = 11375929 | pmc = 1083880 | doi = 10.1093/embo-reports/kve085 }}
  • {{cite journal | vauthors = Tsai MY, Lan KC, Huang KE, Huang FJ, Kung FT, Chang SY | title = Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles | journal = Fertility and Sterility | volume = 80 | issue = 6 | pages = 1437–43 | date = December 2003 | pmid = 14667880 | doi = 10.1016/j.fertnstert.2003.05.015 | doi-access = free }}
  • {{cite journal | vauthors = Seul KH, Kang KY, Lee KS, Kim SH, Beyer EC | title = Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis | journal = Biochemical and Biophysical Research Communications | volume = 319 | issue = 4 | pages = 1144–51 | date = July 2004 | pmid = 15194487 | doi = 10.1016/j.bbrc.2004.05.097 }}
  • {{cite journal | vauthors = Kameritsch P, Khandoga N, Nagel W, Hundhausen C, Lidington D, Pohl U | title = Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules | journal = Journal of Cellular Physiology | volume = 203 | issue = 1 | pages = 233–42 | date = April 2005 | pmid = 15481066 | doi = 10.1002/jcp.20218 | doi-access = free }}

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{{Ion channels|g4}}

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Category:Connexins