GJD3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Gap junction delta-2 (GJD2), also known as connexin-36 (Cx36) or gap junction alpha-9 (GJA9), is a protein that in humans is encoded by the GJD2 gene.{{cite web | title = Entrez Gene: gap junction protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=125111}}
Function
This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=White TW, Srinivas M, Ripps H |title=Virtual cloning, functional expression, and gating analysis of human connexin31.9. |journal=Am. J. Physiol., Cell Physiol. |volume=283 |issue= 3 |pages= C960–70 |year= 2002 |pmid= 12176752 |doi= 10.1152/ajpcell.00163.2002 |display-authors=etal}}
- {{cite journal |vauthors=Gemel J, Lin X, Collins R |title=Cx30.2 can form heteromeric gap junction channels with other cardiac connexins. |journal=Biochem. Biophys. Res. Commun. |volume=369 |issue= 2 |pages= 388–94 |year= 2008 |pmid= 18291099 |doi= 10.1016/j.bbrc.2008.02.040 |pmc=2323682|display-authors=etal}}
- {{cite journal |vauthors=Belluardo N, White TW, Srinivas M |title=Identification and functional expression of HCx31.9, a novel gap junction gene. |journal=Cell Commun. Adhes. |volume=8 |issue= 4–6 |pages= 173–8 |year= 2001 |pmid= 12064584 |doi= 10.3109/15419060109080719|s2cid=13136344 |display-authors=etal}}
- {{cite journal |vauthors=Bukauskas FF, Kreuzberg MM, Rackauskas M |title=Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 25 |pages= 9726–31 |year= 2006 |pmid= 16772377 |doi= 10.1073/pnas.0603372103 |pmc=1480474|bibcode=2006PNAS..103.9726B |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Söhl G, Nielsen PA, Eiberger J, Willecke K |title=Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues. |journal=Cell Commun. Adhes. |volume=10 |issue= 1 |pages= 27–36 |year= 2003|pmid= 12881038 |doi= 10.1080/15419060302063|s2cid=225894 }}
- {{cite journal |vauthors=Kreuzberg MM, Liebermann M, Segschneider S |title=Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system. |journal=J. Mol. Cell. Cardiol. |volume=46 |issue= 4 |pages= 553–9 |year= 2009 |pmid= 19168070 |doi= 10.1016/j.yjmcc.2008.12.007 |display-authors=etal}}
- {{cite journal |vauthors=Unsworth HC, Aasen T, McElwaine S, Kelsell DP |title=Tissue-specific effects of wild-type and mutant connexin 31: a role in neurite outgrowth. |journal=Hum. Mol. Genet. |volume=16 |issue= 2 |pages= 165–72 |year= 2007 |pmid= 17142249 |doi= 10.1093/hmg/ddl452 |doi-access= free }}
- {{cite journal |vauthors=Nielsen PA, Beahm DL, Giepmans BN |title=Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38272–83 |year= 2002 |pmid= 12154091 |doi= 10.1074/jbc.M205348200 |display-authors=etal|doi-access=free }}
{{refend}}
{{NLM content}}
{{Ion channels|g4}}
{{gene-17-stub}}