GLTP
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Glycolipid transfer protein is a protein that in humans is encoded by the GLTP gene.{{cite journal |vauthors=Li XM, Malakhova ML, Lin X, Pike HM, Chung T, Molotkovsky JG, Brown RE | title = Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy | journal = Biochemistry | volume = 43 | issue = 31 | pages = 10285–94 |date=Aug 2004 | pmid = 15287756 | pmc = 2593833 | doi = 10.1021/bi0495432 }}{{cite journal |vauthors=Malakhova ML, Malinina L, Pike HM, Kanack AT, Patel DJ, Brown RE | title = Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex | journal = J Biol Chem | volume = 280 | issue = 28 | pages = 26312–20 |date=Jul 2005 | pmid = 15901739 | pmc = 1393170 | doi = 10.1074/jbc.M500481200 | doi-access = free }}{{cite web | title = Entrez Gene: GLTP glycolipid transfer protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51228}}
The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein.{{cite web | title = Entrez Gene: GLTP glycolipid transfer protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51228}}
References
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Further reading
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- {{cite journal |vauthors=Brown RE, Mattjus P |title=Glycolipid transfer proteins. |journal=Biochim. Biophys. Acta |volume=1771 |issue= 6 |pages= 746–60 |year= 2007 |pmid= 17320476 |doi= 10.1016/j.bbalip.2007.01.011 | pmc=1986823 }}
- {{cite journal | author=Abe A |title=Primary structure of glycolipid transfer protein from pig brain. |journal=J. Biol. Chem. |volume=265 |issue= 17 |pages= 9634–7 |year= 1990 |doi=10.1016/S0021-9258(19)38716-2 |pmid= 2190982 |doi-access=free }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
- {{cite journal |vauthors=Mattjus P, Pike HM, Molotkovsky JG, Brown RE |title=Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers. |journal=Biochemistry |volume=39 |issue= 5 |pages= 1067–75 |year= 2000 |pmid= 10653652 |doi=10.1021/bi991810u | pmc=2637181 }}
- {{cite journal |vauthors=Lin X, Mattjus P, Pike HM |title=Cloning and expression of glycolipid transfer protein from bovine and porcine brain. |journal=J. Biol. Chem. |volume=275 |issue= 7 |pages= 5104–10 |year= 2000 |pmid= 10671554 |doi=10.1074/jbc.275.7.5104 | pmc=2621014 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Malinina L, Malakhova ML, Teplov A |title=Structural basis for glycosphingolipid transfer specificity. |journal=Nature |volume=430 |issue= 7003 |pages= 1048–53 |year= 2004 |pmid= 15329726 |doi= 10.1038/nature02856 | pmc=2640488 |bibcode=2004Natur.430.1048M |display-authors=etal}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Rao CS, Lin X, Pike HM |title=Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses. |journal=Biochemistry |volume=43 |issue= 43 |pages= 13805–15 |year= 2004 |pmid= 15504043 |doi= 10.1021/bi0492197 | pmc=2596630 |display-authors=etal}}
- {{cite journal |vauthors=Rao CS, Chung T, Pike HM, Brown RE |title=Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition. |journal=Biophys. J. |volume=89 |issue= 6 |pages= 4017–28 |year= 2006 |pmid= 16169991 |doi= 10.1529/biophysj.105.070631 | pmc=1366967 }}
- {{cite journal |vauthors=Malinina L, Malakhova ML, Kanack AT |title=The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure. |journal=PLOS Biol. |volume=4 |issue= 11 |pages= e362 |year= 2006 |pmid= 17105344 |doi= 10.1371/journal.pbio.0040362 | pmc=1618416 |display-authors=etal |doi-access=free }}
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{{PDB Gallery|geneid=51228}}
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