GME

• GameStop (stock ticker symbol GME), an American video game retailer
• General Microelectronics, a defunct American semiconductor manufacturer
• General Motors Egypt
• General Motors Europe
• Green Mountain Energy, American company
• Guardian Media Entertainment, collaboration between the National Hockey League and comics creator Stan Lee

• Gaelic medium education in Scotland
• Graduate medical education

• East Germanic languages
• FCA Global Medium Engine, an engine from Stellantis
• GME of Deutscher Wetterdienst, weather prediction model of the German Weather Service
• Generic Modeling Environment, software modelling tool
• Granulomatous meningoencephalitis, disease of the central nervous system of dogs and, rarely, cats
• Greater Middle East, a region

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