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GNAO1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene.{{cite journal |author1=Murtagh JJ Jr |author2=Eddy R |author3=Shows TB |author4=Moss J |author5=Vaughan M | title = Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16 | journal = Mol Cell Biol | volume = 11 | issue = 2 | pages = 1146–55 |date=Mar 1991 | pmid = 1899283 | pmc = 359797 | doi = 10.1128/MCB.11.2.1146}}{{cite journal |vauthors=Kinoshita M, Nukada T, Asano T, Mori Y, Akaike A, Satoh M, Kaneko S | title = Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels | journal = J Biol Chem | volume = 276 | issue = 31 | pages = 28731–8 |date=Jul 2001 | pmid = 11395521 | doi = 10.1074/jbc.M104806200 | doi-access = free }}{{cite web | title = Entrez Gene: GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2775}}

Mutations in this gene have been shown to cause epileptic encephalopathy.{{cite journal |vauthors=Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, Terashima H, Osaka H, Nakamura S, Tohyama J, Kumada T, Furukawa T, Iwata S, Shiihara T, Kubota M, Miyatake S, Koshimizu E, Nishiyama K, Nakashima M, Tsurusaki Y, Miyake N, Hayasaka K, Ogata K, Fukuda A, Matsumoto N, Saitsu H | title = De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy | journal = Am. J. Hum. Genet. | volume = 93 | issue = 3 | pages = 496–505 |date=September 2013 | pmid = 23993195 | doi = 10.1016/j.ajhg.2013.07.014 | pmc=3769919}}

Interactions

GNAO1 has been shown to interact with:

  • RGS5,{{cite journal |vauthors=Chen C, Zheng B, Han J, Lin SC | title = Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast | journal = J. Biol. Chem. | volume = 272 | issue = 13 | pages = 8679–85 | year = 1997 | pmid = 9079700 | doi = 10.1074/jbc.272.13.8679| doi-access = free }}{{cite journal |vauthors=Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S | title = Characterization of RGS5 in regulation of G protein-coupled receptor signaling | journal = Life Sci. | volume = 68 | issue = 13 | pages = 1457–69 | year = 2001 | pmid = 11253162 | doi = 10.1016/S0024-3205(01)00939-0}}
  • RGS19,{{cite journal |vauthors=De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG | title = GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 26 | pages = 15203–8 | year = 1996 | pmid = 8986788 | pmc = 26381 | doi = 10.1073/pnas.93.26.15203| bibcode = 1996PNAS...9315203D | doi-access = free }}{{cite journal |vauthors=Woulfe DS, Stadel JM | title = Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP | journal = J. Biol. Chem. | volume = 274 | issue = 25 | pages = 17718–24 | year = 1999 | pmid = 10364213 | doi = 10.1074/jbc.274.25.17718| doi-access = free }}
  • RGS20,{{cite journal |vauthors=Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R | title = Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways | journal = Cell. Signal. | volume = 20 | issue = 6 | pages = 1190–7 | year = 2008 | pmid = 18407463 | pmc = 3107604 | doi = 10.1016/j.cellsig.2008.02.008 }} and
  • RIC8A{{cite journal |vauthors=Tall GG, Krumins AM, Gilman AG | title = Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8356–62 | year = 2003 | pmid = 12509430 | doi = 10.1074/jbc.M211862200 | doi-access = free }}

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Raymond JR, Mukhin YV, Gelasco A |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2–3 |pages= 179–212 |year= 2002 |pmid= 11916537 |doi=10.1016/S0163-7258(01)00169-3 |display-authors=etal}}
  • {{cite journal |vauthors=Coupry I, Duzic E, Lanier SM |title=Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go. |journal=J. Biol. Chem. |volume=267 |issue= 14 |pages= 9852–7 |year= 1992 |doi=10.1016/S0021-9258(19)50172-7 |pmid= 1349607 |doi-access=free }}
  • {{cite journal |vauthors=Denker BM, Neer EJ, Schmidt CJ |title=Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 6272–7 |year= 1992 |doi=10.1016/S0021-9258(18)42691-9 |pmid= 1556134 |doi-access=free }}
  • {{cite journal |vauthors=Yi F, Denker BM, Neer EJ |title=Structural and functional studies of cross-linked Go protein subunits. |journal=J. Biol. Chem. |volume=266 |issue= 6 |pages= 3900–6 |year= 1991 |doi=10.1016/S0021-9258(19)67879-8 |pmid= 1899868 |doi-access=free }}
  • {{cite journal |vauthors=Tsukamoto T, Toyama R, Itoh H |title=Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 8 |pages= 2974–8 |year= 1991 |pmid= 1901650 |doi=10.1073/pnas.88.8.2974 | pmc=51366 |bibcode=1991PNAS...88.2974T |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Gabrion J, Brabet P, Nguyen Than Dao B |title=Ultrastructural localization of the GTP-binding protein Go in neurons. |journal=Cell. Signal. |volume=1 |issue= 1 |pages= 107–23 |year= 1990 |pmid= 2518353 |doi=10.1016/0898-6568(89)90025-9 |display-authors=etal}}
  • {{cite journal |vauthors=Lavu S, Clark J, Swarup R |title=Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha. |journal=Biochem. Biophys. Res. Commun. |volume=150 |issue= 2 |pages= 811–5 |year= 1988 |pmid= 3124840 |doi=10.1016/0006-291X(88)90463-9 |display-authors=etal|url=https://zenodo.org/record/1253798 }}
  • {{cite journal |vauthors=Zumbihl R, Breuiller-Fouché M, Carrette J |title=Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium. |journal=Eur. J. Pharmacol. |volume=288 |issue= 1 |pages= 9–15 |year= 1995 |pmid= 7705473 |doi= 10.1016/0922-4106(94)90004-3|display-authors=etal}}
  • {{cite journal |vauthors=Grassie MA, Milligan G |title=Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts. |journal=Biochem. J. |volume=306 |issue= 2|pages= 525–30 |year= 1995 |pmid= 7887906 |doi= 10.1042/bj3060525| pmc=1136549 }}
  • {{cite journal |vauthors=Wu HC, Lin CT |title=Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis. |journal=Lab. Invest. |volume=71 |issue= 2 |pages= 175–81 |year= 1994 |pmid= 8078296 }}
  • {{cite journal |vauthors=Nitta K, Uchida K, Kawashima A |title=Identification of GTP-binding proteins in human glomeruli. |journal=Nippon Jinzo Gakkai Shi |volume=36 |issue= 1 |pages= 9–12 |year= 1994 |pmid= 8107314 |display-authors=etal}}
  • {{cite journal |vauthors=Georgoussi Z, Carr C, Milligan G |title=Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go. |journal=Mol. Pharmacol. |volume=44 |issue= 1 |pages= 62–9 |year= 1993 |pmid= 8393523 }}
  • {{cite journal |vauthors=Laugwitz KL, Allgeier A, Offermanns S |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116–20 |year= 1996 |pmid= 8552586 |doi=10.1073/pnas.93.1.116 | pmc=40189 |bibcode=1996PNAS...93..116L |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Kawano N, Ito T, Kitamura H |title=Immunoexpression of the alpha subunit of a guanine nucleotide-binding protein (Go) in pulmonary neuroendocrine cells and neoplasms. |journal=Pathol. Int. |volume=46 |issue= 6 |pages= 393–8 |year= 1997 |pmid= 8869990 |doi=10.1111/j.1440-1827.1996.tb03629.x |s2cid=35816963 |display-authors=etal}}
  • {{cite journal |vauthors=De Vries L, Elenko E, Hubler L |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15203–8 |year= 1997 |pmid= 8986788 |doi=10.1073/pnas.93.26.15203 | pmc=26381 |bibcode=1996PNAS...9315203D |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Valenzuela D, Han X, Mende U |title=G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 5 |pages= 1727–32 |year= 1997 |pmid= 9050846 |doi=10.1073/pnas.94.5.1727 | pmc=19984 |bibcode=1997PNAS...94.1727V |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Chen C, Zheng B, Han J, Lin SC |title=Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8679–85 |year= 1997 |pmid= 9079700 |doi=10.1074/jbc.272.13.8679 |doi-access=free }}
  • {{cite journal |vauthors=Natochin M, Lipkin VM, Artemyev NO |title=Interaction of human retinal RGS with G-protein alpha-subunits. |journal=FEBS Lett. |volume=411 |issue= 2–3 |pages= 179–82 |year= 1997 |pmid= 9271201 |doi=10.1016/S0014-5793(97)00687-X |s2cid=84269212 |doi-access=free }}
  • {{cite journal |vauthors=Busconi L, Denker BM |title=Analysis of the N-terminal binding domain of Go alpha. |journal=Biochem. J. |volume=328 |issue= 1|pages= 23–31 |year= 1998 |pmid= 9359829 |doi= 10.1042/bj3280023| pmc=1218882 }}

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{{Intracellular signaling peptides and proteins}}

{{gene-16-stub}}