GNAT1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Guanine nucleotide-binding protein G(t) subunit alpha-1 is a protein that in humans is encoded by the GNAT1 gene.{{cite web | title = Entrez Gene: GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2779}}

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. Alternative splicing of this gene results in two transcript variants.

References

{{cite journal |vauthors=Wilkie TM, Gilbert DJ, Olsen AS |title=Evolution of the mammalian G protein alpha subunit multigene family. |journal=Nat. Genet. |volume=1 |issue= 2 |pages= 85–91 |year= 1993 |pmid= 1302014 |doi= 10.1038/ng0592-85 |s2cid=31888533 |display-authors=etal|url=https://zenodo.org/record/1233383 }}
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{{cite journal | author=Fong SL |title=Characterization of the human rod transducin alpha-subunit gene. |journal=Nucleic Acids Res. |volume=20 |issue= 11 |pages= 2865–70 |year= 1992 |pmid= 1614872 |doi=10.1093/nar/20.11.2865 | pmc=336934 }}
{{cite journal |vauthors=Lerea CL, Bunt-Milam AH, Hurley JB |title=Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina. |journal=Neuron |volume=3 |issue= 3 |pages= 367–76 |year= 1990 |pmid= 2534964 |doi=10.1016/0896-6273(89)90261-4 |s2cid=2870440 }}
{{cite journal |vauthors=Van Dop C, Medynski DC, Apone LM |title=Nucleotide sequence for a cDNA encoding the alpha subunit of retinal transducin (GNAT1) isolated from the human eye. |journal=Nucleic Acids Res. |volume=17 |issue= 12 |pages= 4887 |year= 1989 |pmid= 2748346 |doi=10.1093/nar/17.12.4887 | pmc=318051 }}
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{{cite journal |vauthors=Ngo JT, Bateman JB, Klisak I |title=Regional mapping of a human rod alpha-transducin (GNAT1) gene to chromosome 3p22. |journal=Genomics |volume=18 |issue= 3 |pages= 724–5 |year= 1994 |pmid= 8307584 |doi=10.1016/S0888-7543(05)80384-2 |display-authors=etal}}
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{{cite journal |vauthors=Chen CK, Wieland T, Simon MI |title=RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 12885–9 |year= 1996 |pmid= 8917514 |doi=10.1073/pnas.93.23.12885 | pmc=24015 |bibcode=1996PNAS...9312885C |doi-access=free }}
{{cite journal |vauthors=Seibert C, Harteneck C, Ernst OP |title=Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells. |journal=Eur. J. Biochem. |volume=266 |issue= 3 |pages= 911–6 |year= 2000 |pmid= 10583385 |doi=10.1046/j.1432-1327.1999.00927.x |display-authors=etal|doi-access= }}
{{cite journal |vauthors=Wieland T, Bahtijari N, Zhou XB |title=Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28500–6 |year= 2000 |pmid= 10878019 |doi= 10.1074/jbc.M004187200 |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Bell MW, Desai N, Guo XX, Ghalayini AJ |s2cid=17501930 |title=Tyrosine phosphorylation of the alpha subunit of transducin and its association with Src in photoreceptor rod outer segments. |journal=J. Neurochem. |volume=75 |issue= 5 |pages= 2006–19 |year= 2000 |pmid= 11032890 |doi=10.1046/j.1471-4159.2000.0752006.x |doi-access= }}
{{cite journal |vauthors=Hu G, Wensel TG |title=R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 15 |pages= 9755–60 |year= 2002 |pmid= 12119397 |doi= 10.1073/pnas.152094799 | pmc=125004 |bibcode=2002PNAS...99.9755H |doi-access=free }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
{{cite journal |vauthors=Muzny DM, Scherer SE, Kaul R |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 |bibcode=2006Natur.440.1194M |display-authors=etal|doi-access=free }}

External links

{{PDBe-KB2|P11488|Guanine nucleotide-binding protein G(t) subunit alpha-1}}

GNAT1

References

Further reading

External links