GNG3

{{Short description|Protein-coding gene in the species Homo sapiens}}

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.{{cite journal |vauthors=Downes GB, Gautam N | title = The G protein subunit gene families | journal = Genomics | volume = 62 | issue = 3 | pages = 544–52 |date=Mar 2000 | pmid = 10644457 | doi = 10.1006/geno.1999.5992 }}{{cite web | title = Entrez Gene: GNG3 guanine nucleotide binding protein (G protein), gamma 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2785}}

G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM]

References

{{cite journal |vauthors=Wedegaertner PB, Wilson PT, Bourne HR |title=Lipid modifications of trimeric G proteins. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 503–6 |year= 1995 |pmid= 7822269 |doi=10.1074/jbc.270.2.503 |doi-access=free }}
{{cite journal |vauthors=Garcia-Higuera I, Thomas TC, Yi F, Neer EJ |title=Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma. |journal=J. Biol. Chem. |volume=271 |issue= 1 |pages= 528–35 |year= 1996 |pmid= 8550614 |doi= 10.1074/jbc.271.1.528|doi-access=free }}
{{cite journal |vauthors=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141–6 |year= 1996 |pmid= 8636150 |doi=10.1074/jbc.271.12.7141 |doi-access=free }}
{{cite journal |vauthors=Morishita R, Saga S, Kawamura N |title=Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain. |journal=J. Neurochem. |volume=68 |issue= 2 |pages= 820–7 |year= 1997 |pmid= 9003074 |doi=10.1046/j.1471-4159.1997.68020820.x |s2cid=83968908 |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Bell B, Xing H, Yan K |title=KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7982–6 |year= 1999 |pmid= 10075696 |doi=10.1074/jbc.274.12.7982 |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Hurowitz EH, Melnyk JM, Chen YJ |title=Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. |journal=DNA Res. |volume=7 |issue= 2 |pages= 111–20 |year= 2000 |pmid= 10819326 |doi=10.1093/dnares/7.2.111 |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB |title=Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23945–53 |year= 2001 |pmid= 11294873 |doi= 10.1074/jbc.M101154200 |doi-access= free }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Cuello F, Schulze RA, Heemeyer F |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220–6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Kato C, Mizutani T, Tamaki H |title=Characterization of heterotrimeric G protein complexes in rice plasma membrane |journal=Plant J. |volume=38 |issue= 2 |pages= 320–31 |year= 2004 |pmid= 15078334 |doi= 10.1111/j.1365-313X.2004.02046.x |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Schwindinger WF, Giger KE, Betz KS |title=Mice with Deficiency of G Protein γ3 Are Lean and Have Seizures |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7758–68 |year= 2004 |pmid= 15314181 |doi= 10.1128/MCB.24.17.7758-7768.2004 | pmc=506985 |display-authors=etal}}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}

GNG3

References

Further reading