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GOLGA1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Golgin subfamily A member 1 is a protein that in humans is encoded by the GOLGA1 gene.{{cite journal | vauthors = Griffith KJ, Chan EK, Lung CC, Hamel JC, Guo X, Miyachi K, Fritzler MJ | title = Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome | journal = Arthritis and Rheumatism | volume = 40 | issue = 9 | pages = 1693–1702 | date = September 1997 | pmid = 9324025 | doi = 10.1002/art.1780400920 | doi-access = free }}{{cite web | title = Entrez Gene: GOLGA1 golgi autoantigen, golgin subfamily a, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2800}}

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein is associated with Sjogren's syndrome.

Interactions

GOLGA1 has been shown to interact with ARL1.{{cite journal | vauthors = Lu L, Hong W | title = Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi | journal = Molecular Biology of the Cell | volume = 14 | issue = 9 | pages = 3767–3781 | date = September 2003 | pmid = 12972563 | pmc = 196566 | doi = 10.1091/mbc.E03-01-0864 }}

References

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Further reading

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  • {{cite journal | vauthors = Barr FA | title = A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins | journal = Current Biology | volume = 9 | issue = 7 | pages = 381–384 | date = April 1999 | pmid = 10209123 | doi = 10.1016/S0960-9822(99)80167-5 | s2cid = 14404566 | doi-access = free | bibcode = 1999CBio....9..381B }}
  • {{cite journal | vauthors = Lu L, Hong W | title = Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi | journal = Molecular Biology of the Cell | volume = 14 | issue = 9 | pages = 3767–3781 | date = September 2003 | pmid = 12972563 | pmc = 196566 | doi = 10.1091/mbc.E03-01-0864 }}
  • {{cite journal | vauthors = Lu L, Tai G, Hong W | title = Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network | journal = Molecular Biology of the Cell | volume = 15 | issue = 10 | pages = 4426–4443 | date = October 2004 | pmid = 15269279 | pmc = 519138 | doi = 10.1091/mbc.E03-12-0872 }}
  • {{cite journal | vauthors = Luke MR, Houghton F, Perugini MA, Gleeson PA | title = The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers | journal = The Biochemical Journal | volume = 388 | issue = Pt 3 | pages = 835–841 | date = June 2005 | pmid = 15654769 | pmc = 1183463 | doi = 10.1042/BJ20041810 }}
  • {{cite journal | vauthors = Lock JG, Hammond LA, Houghton F, Gleeson PA, Stow JL | title = E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97 | journal = Traffic | volume = 6 | issue = 12 | pages = 1142–1156 | date = December 2005 | pmid = 16262725 | doi = 10.1111/j.1600-0854.2005.00349.x | s2cid = 32851401 | doi-access = free }}
  • {{cite journal | vauthors = Alzhanova D, Hruby DE | title = A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis | journal = Virology | volume = 362 | issue = 2 | pages = 421–427 | date = June 2007 | pmid = 17276477 | pmc = 2680701 | doi = 10.1016/j.virol.2007.01.003 }}

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