GPHA2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Glycoprotein hormone alpha-2 is a protein that in humans is encoded by the GPHA2 gene.{{cite journal |vauthors=Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ | title = Activation of orphan receptors by the hormone relaxin | journal = Science | volume = 295 | issue = 5555 | pages = 671–4 |date=Jan 2002 | pmid = 11809971 | doi = 10.1126/science.1065654 | bibcode = 2002Sci...295..671H | s2cid = 32693420 }}{{cite web | title = Entrez Gene: GPHA2 glycoprotein hormone alpha 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=170589}}
GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002). (Supplied by OMIM.)
References
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7. Z. Gong, W. Wang, K. El Omari, A. A. Lebedev, O. B. Clarke, W. A. Hendrickson, Crystal structure of LGR ligand alpha2/beta5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones. Proc Natl Acad Sci U S A 120 (1), e2218630120 (2023). https://www.pnas.org/doi/10.1073/pnas.2218630120#
Further reading
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- {{cite journal |vauthors=Suzuki C, Nagasaki H, Okajima Y |title=The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin |journal=Regul. Pept. |volume=142 |issue= 1–2 |pages= 60–7 |year= 2007 |pmid= 17363077 |doi= 10.1016/j.regpep.2007.01.009 |s2cid=24382046 |display-authors=etal}}
- {{cite journal |vauthors=Breous E, Wenzel A, Loos U |title=Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit |journal=Mol. Cell. Endocrinol. |volume=245 |issue= 1–2 |pages= 169–80 |year= 2006 |pmid= 16376481 |doi= 10.1016/j.mce.2005.11.009 |s2cid=21211666 }}
- {{cite journal |vauthors=Sudo S, Kuwabara Y, Park JI |title=Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5 |journal=Endocrinology |volume=146 |issue= 8 |pages= 3596–604 |year= 2005 |pmid= 15890769 |doi= 10.1210/en.2005-0317 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Hsu SY, Nakabayashi K, Bhalla A |title=Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5 |journal=Mol. Endocrinol. |volume=16 |issue= 7 |pages= 1538–51 |year= 2003 |pmid= 12089349 |doi=10.1210/mend.16.7.0871 |doi-access=free }}
- {{cite journal |vauthors=Nakabayashi K, Matsumi H, Bhalla A |title=Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor |journal=J. Clin. Invest. |volume=109 |issue= 11 |pages= 1445–52 |year= 2002 |pmid= 12045258 |doi= 10.1172/JCI14340 | pmc=150994 |display-authors=etal}}
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