GPR101
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Probable G-protein coupled receptor 101 is a protein that is encoded by the GPR101 gene in humans.{{cite journal |vauthors=Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF | title = Discovery and mapping of ten novel G protein-coupled receptor genes | journal = Gene | volume = 275 | issue = 1 | pages = 83–91 | date = Sep 2001 | pmid = 11574155 | doi = 10.1016/S0378-1119(01)00651-5 }}{{cite web | title = Entrez Gene: GPR101 G protein-coupled receptor 101| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83550}}
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
Clinical significance
A duplication event in GPR101 is implicated in cases of gigantism and acromegaly.{{cite journal | vauthors= Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra MD, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA | title = Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation | journal = N. Engl. J. Med. | volume = 371| issue = 25| year = 2014 | pmid = 25470569 | doi = 10.1056/NEJMoa1408028 | pages=2363–74 | pmc=4291174}}
References
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Further reading
- {{cite journal | vauthors = Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence | journal = FEBS Lett. | volume = 520 | issue = 1–3 | pages = 97–101 | year = 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 | s2cid = 7116392 | doi-access = }}
{{G protein-coupled receptors}}
Category:G protein-coupled receptors
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