GPR123
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene.{{cite journal |vauthors=Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB | title = There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini | journal = Biochem Biophys Res Commun | volume = 301 | issue = 3 | pages = 725–34 |date=Feb 2003 | pmid = 12565841 | doi =10.1016/S0006-291X(03)00026-3 }}{{cite web | title = Entrez Gene: GPR123 G protein-coupled receptor 123| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84435}} It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.{{cite book |vauthors=Stacey M, Yona S | title = AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | isbn = 978-1-4419-7912-4 }}{{cite journal |vauthors=Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB | title = Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions | journal = FEBS Lett | volume = 531 | issue = 3 | pages = 407–14 |date=Nov 2002 | pmid = 12435584 | doi =10.1016/S0014-5793(02)03574-3 | s2cid = 7449692 | doi-access = free }}{{cite journal |vauthors=Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = EMBO J. | volume = 31 | issue = 6 | pages = 1364–78 |date=March 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 }}
References
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Further reading
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- {{cite journal |vauthors=Vassilatis DK, Hohmann JG, Zeng H |title=The G protein-coupled receptor repertoires of human and mouse |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4903–8 |year= 2003 |pmid= 12679517 |doi= 10.1073/pnas.0230374100 | pmc=153653 |bibcode=2003PNAS..100.4903V |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |bibcode=2004Natur.429..375D |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Bjarnadóttir TK, Fredriksson R, Höglund PJ |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 |display-authors=etal}}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
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{{G protein-coupled receptors}}
Category:G protein-coupled receptors
{{transmembranereceptor-stub}}